Expression of ERAP2 in cancer - Summary - The Human Protein Atlas

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ERAP2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ERAP2
Gene description	Endoplasmic reticulum aminopeptidase 2
Protein class	Enzymes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (CAPAN-2, TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA034498 , CAB025618
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034498	CAB025618

GENE INFORMATION
Gene name	ERAP2 (HGNC Symbol)
Synonyms	L-RAP, LRAP
Description	Endoplasmic reticulum aminopeptidase 2 (HGNC Symbol)
Entrez gene summary	Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q15
Chromosome location (bp)	96875939 - 96919716
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164308 (version 83.38)
Entrez gene	64167
UniProt	Q6P179 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P179
Antibodypedia	ERAP2 antibodies

PROTEIN BROWSER

ERAP2-001	ERAP2-002	ERAP2-005	ERAP2-006	ERAP2-007	ERAP2-008	ERAP2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ERAP2-001 ENSP00000400376 ENST00000437043	Q6P179 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0004177 [aminopeptidase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0008217 [regulation of blood pressure] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	960 aa 110.5 kDa	Yes	0
ERAP2-002 ENSP00000421175 ENST00000510373	D6RGW0 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	694 aa 79.7 kDa	Yes	0
ERAP2-005 ENSP00000425758 ENST00000510309	Q6P179 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0004177 [aminopeptidase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0008217 [regulation of blood pressure] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	350 aa 40.1 kDa	Yes	0
ERAP2-006 ENSP00000369235 ENST00000379904	Q6P179 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	Enzymes Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0004177 [aminopeptidase activity] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0008217 [regulation of blood pressure] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I] GO:0042277 [peptide binding] GO:0043171 [peptide catabolic process] GO:0070006 [metalloaminopeptidase activity] Show all	915 aa 105.5 kDa	Yes	0
ERAP2-007 ENSP00000426655 ENST00000507346	D6RF46 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.2 kDa	No	0
ERAP2-008 ENSP00000427573 ENST00000508077	H0YAL8 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] Show all	163 aa 19 kDa	No	0
ERAP2-011 ENSP00000425415 ENST00000512869	H0Y9X9 [Direct mapping] Endoplasmic reticulum aminopeptidase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] Show all	79 aa 9 kDa	No	0

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