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ERAP2

GENERAL INFORMATION

Gene name

 ERAP2

Gene description

 Endoplasmic reticulum aminopeptidase 2

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, including immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA034498 , CAB025618
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ERAP2 (HGNC Symbol)

Synonyms

 L-RAP, LRAP

Description

 Endoplasmic reticulum aminopeptidase 2 (HGNC Symbol)

Entrez gene summary

 Aminopeptidases hydrolyze N-terminal amino acids of proteins or peptide substrates. Major histocompatibility complex (MHC) class I molecules rely on aminopeptidases such as ERAP1 (MIM 606832) and LRAP to trim precursors to antigenic peptides in the endoplasmic reticulum (ER) following cleavage in the cytoplasm by tripeptidyl peptidase II (TPP2; MIM 190470) (Tanioka et al., 2003 [PubMed 12799365]).[supplied by OMIM, Mar 2008]

Chromosome

 5

Cytoband

 q15

Chromosome location (bp)

 96875939 - 96919716

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164308 (version 83.38)

Entrez gene

 64167

UniProt

 Q6P179 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6P179

Antibodypedia

 ERAP2 antibodies

PROTEIN BROWSER
ERAP2-001
ERAP2-002
ERAP2-005
ERAP2-006
ERAP2-007
ERAP2-008
ERAP2-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ERAP2-001
ENSP00000400376
ENST00000437043
Q6P179 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004177 [aminopeptidase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0070006 [metalloaminopeptidase activity]
Show all
 960 aa
110.5 kDa 		Yes 0
ERAP2-002
ENSP00000421175
ENST00000510373
D6RGW0 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
Show all
 694 aa
79.7 kDa 		Yes 0
ERAP2-005
ENSP00000425758
ENST00000510309
Q6P179 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004177 [aminopeptidase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0070006 [metalloaminopeptidase activity]
Show all
 350 aa
40.1 kDa 		Yes 0
ERAP2-006
ENSP00000369235
ENST00000379904
Q6P179 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
Enzymes
   Peptidases
   Metallopeptidases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I]
GO:0004177 [aminopeptidase activity]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0008217 [regulation of blood pressure]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0019885 [antigen processing and presentation of endogenous peptide antigen via MHC class I]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0070006 [metalloaminopeptidase activity]
Show all
 915 aa
105.5 kDa 		Yes 0
ERAP2-007
ENSP00000426655
ENST00000507346
D6RF46 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3.2 kDa 		No 0
ERAP2-008
ENSP00000427573
ENST00000508077
H0YAL8 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
Show all
 163 aa
19 kDa 		No 0
ERAP2-011
ENSP00000425415
ENST00000512869
H0Y9X9 [Direct mapping]
Endoplasmic reticulum aminopeptidase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
Show all
 79 aa
9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.