Expression of PDSS2 in cancer - Summary - The Human Protein Atlas

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PDSS2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDSS2
Gene description	Prenyl (decaprenyl) diphosphate synthase, subunit 2
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA029685 , HPA029686
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), breast cancer (unfavourable) and colorectal cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029685	HPA029686

GENE INFORMATION
Gene name	PDSS2 (HGNC Symbol)
Synonyms	bA59I9.3, C6orf210
Description	Prenyl (decaprenyl) diphosphate synthase, subunit 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	107152557 - 107459564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164494 (version 83.38)
Entrez gene	57107
UniProt	Q86YH6 (UniProt - Evidence at protein level)
neXtProt	NX_Q86YH6
Antibodypedia	PDSS2 antibodies

PROTEIN BROWSER

PDSS2-001	PDSS2-002	PDSS2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDSS2-001 ENSP00000358033 ENST00000369037	Q86YH6 [Direct mapping] Decaprenyl-diphosphate synthase subunit 2 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000010 [trans-hexaprenyltranstransferase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006744 [ubiquinone biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] GO:0050347 [trans-octaprenyltranstransferase activity] GO:0050878 [regulation of body fluid levels] GO:0051290 [protein heterotetramerization] GO:1990234 [transferase complex] Show all	399 aa 44.1 kDa	No	0
PDSS2-002 ENSP00000358027 ENST00000369031	Q86YH6 [Direct mapping] Decaprenyl-diphosphate synthase subunit 2 Show all	Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000010 [trans-hexaprenyltranstransferase activity] GO:0005737 [cytoplasm] GO:0005759 [mitochondrial matrix] GO:0006744 [ubiquinone biosynthetic process] GO:0008299 [isoprenoid biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0046982 [protein heterodimerization activity] GO:1990234 [transferase complex] Show all	240 aa 26.4 kDa	No	0
PDSS2-003 ENSP00000392613 ENST00000449027	Q5JRD6 [Direct mapping] Decaprenyl-diphosphate synthase subunit 2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.