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PDSS2

GENERAL INFORMATION

Gene name

 PDSS2

Gene description

 Prenyl (decaprenyl) diphosphate synthase, subunit 2

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA029685 , HPA029686
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDSS2 (HGNC Symbol)

Synonyms

 bA59I9.3, C6orf210

Description

 Prenyl (decaprenyl) diphosphate synthase, subunit 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme that synthesizes the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. Defects in this gene are a cause of coenzyme Q10 deficiency.[provided by RefSeq, Oct 2009]

Chromosome

 6

Cytoband

 q21

Chromosome location (bp)

 107152557 - 107459564

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164494 (version 83.38)

Entrez gene

 57107

UniProt

 Q86YH6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86YH6

Antibodypedia

 PDSS2 antibodies

PROTEIN BROWSER
PDSS2-001
PDSS2-002
PDSS2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDSS2-001
ENSP00000358033
ENST00000369037
Q86YH6 [Direct mapping]
Decaprenyl-diphosphate synthase subunit 2
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000010 [trans-hexaprenyltranstransferase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0050347 [trans-octaprenyltranstransferase activity]
GO:0050878 [regulation of body fluid levels]
GO:0051290 [protein heterotetramerization]
GO:1990234 [transferase complex]
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 399 aa
44.1 kDa 		No 0
PDSS2-002
ENSP00000358027
ENST00000369031
Q86YH6 [Direct mapping]
Decaprenyl-diphosphate synthase subunit 2
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000010 [trans-hexaprenyltranstransferase activity]
GO:0005737 [cytoplasm]
GO:0005759 [mitochondrial matrix]
GO:0006744 [ubiquinone biosynthetic process]
GO:0008299 [isoprenoid biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0046982 [protein heterodimerization activity]
GO:1990234 [transferase complex]
Show all
 240 aa
26.4 kDa 		No 0
PDSS2-003
ENSP00000392613
ENST00000449027
Q5JRD6 [Direct mapping]
Decaprenyl-diphosphate synthase subunit 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Ezkurdia et al 2014)
Show all
 80 aa
9.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.