Expression of STEAP1 in cancer - Summary - The Human Protein Atlas

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STEAP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STEAP1
Gene description	Six transmembrane epithelial antigen of the prostate 1
Protein class	Cancer-related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Cell line enhanced (CAPAN-2, U-138 MG)
HPA (normal tissue):	Tissue enhanced (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in brain, pneumocytes and subset of prostate glandular cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA030985
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030985

GENE INFORMATION
Gene name	STEAP1 (HGNC Symbol)
Synonyms	PRSS24, STEAP
Description	Six transmembrane epithelial antigen of the prostate 1 (HGNC Symbol)
Entrez gene summary	This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q21.13
Chromosome location (bp)	90154375 - 90164829
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164647 (version 83.38)
Entrez gene	26872
UniProt	Q9UHE8 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UHE8
Antibodypedia	STEAP1 antibodies

PROTEIN BROWSER

STEAP1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STEAP1-001 ENSP00000297205 ENST00000297205	Q9UHE8 [Direct mapping] Metalloreductase STEAP1 Show all	Transporters Transport Electron Carriers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0010008 [endosome membrane] GO:0015267 [channel activity] GO:0016020 [membrane] GO:0046872 [metal ion binding] GO:0055072 [iron ion homeostasis] GO:0055085 [transmembrane transport] Show all	339 aa 39.9 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.