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STEAP1

GENERAL INFORMATION

Gene name

 STEAP1

Gene description

 Six transmembrane epithelial antigen of the prostate 1

Protein class

 Cancer-related genes
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (prostate)
GTEx:Tissue enhanced (prostate)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in brain, pneumocytes and subset of prostate glandular cells.

DATA RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA030985
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (prostate)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 STEAP1 (HGNC Symbol)

Synonyms

 PRSS24, STEAP

Description

 Six transmembrane epithelial antigen of the prostate 1 (HGNC Symbol)

Entrez gene summary

 This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q21.13

Chromosome location (bp)

 90154375 - 90164829

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164647 (version 83.38)

Entrez gene

 26872

UniProt

 Q9UHE8 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9UHE8

Antibodypedia

 STEAP1 antibodies

PROTEIN BROWSER
STEAP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
STEAP1-001
ENSP00000297205
ENST00000297205
Q9UHE8 [Direct mapping]
Metalloreductase STEAP1
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Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0010008 [endosome membrane]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
GO:0055072 [iron ion homeostasis]
GO:0055085 [transmembrane transport]
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 339 aa
39.9 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.