Fields »
ABOUT
HELP
BLOG
DEFA5

GENERAL INFORMATION

Gene name

 DEFA5

Gene description

 Defensin, alpha 5, Paneth cell-specific

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, small intestine)
GTEx:Tissue enriched (small intestine)
FANTOM5:Group enriched (colon, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in intestinal Paneth cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA015775 , CAB069919
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (colon, small intestine)

GENE INFORMATION

Gene name

 DEFA5 (HGNC Symbol)

Synonyms

 DEF5, HD-5

Description

 Defensin, alpha 5, Paneth cell-specific (HGNC Symbol)

Entrez gene summary

 Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several of the alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 5, is highly expressed in the secretory granules of Paneth cells of the ileum. [provided by RefSeq, Oct 2014]

Chromosome

 8

Cytoband

 p23.1

Chromosome location (bp)

 7055304 - 7056734

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164816 (version 83.38)

Entrez gene

 1670

UniProt

 Q01523 (UniProt - Evidence at protein level)

neXtProt

 NX_Q01523

Antibodypedia

 DEFA5 antibodies

PROTEIN BROWSER
DEFA5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DEFA5-001
ENSP00000329890
ENST00000330590
Q01523 [Direct mapping]
Defensin-5 HD5(23-94) HD5(29-94) HD5(56-94) HD5(63-94)
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005796 [Golgi lumen]
GO:0006952 [defense response]
GO:0019731 [antibacterial humoral response]
GO:0030133 [transport vesicle]
GO:0031640 [killing of cells of other organism]
GO:0034774 [secretory granule lumen]
GO:0045087 [innate immune response]
GO:0050832 [defense response to fungus]
Show all
 94 aa
10.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.