Expression of FASTK in cancer - Summary - The Human Protein Atlas

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FASTK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FASTK
Gene description	Fas-activated serine/threonine kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA031621 , CAB032539
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and colorectal cancer (unfavourable).
Pancreatic cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031621	CAB032539

GENE INFORMATION
Gene name	FASTK (HGNC Symbol)
Synonyms	FAST
Description	Fas-activated serine/threonine kinase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q36.1
Chromosome location (bp)	151076593 - 151080866
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164896 (version 83.38)
Entrez gene	10922
UniProt	Q14296 (UniProt - Evidence at protein level)
neXtProt	NX_Q14296
Antibodypedia	FASTK antibodies

PROTEIN BROWSER

FASTK-004	FASTK-005	FASTK-006	FASTK-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FASTK-004 ENSP00000418516 ENST00000482571	Q14296 [Direct mapping] Fas-activated serine/threonine kinase Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0033867 [Fas-activated serine/threonine kinase activity] GO:0043484 [regulation of RNA splicing] GO:0097190 [apoptotic signaling pathway] Show all	522 aa 58.2 kDa	No	0
FASTK-005 ENSP00000297532 ENST00000297532	Q14296 [Direct mapping] Fas-activated serine/threonine kinase A0A090N8Z7 [Target identity:100%; Query identity:100%] FAST kinase Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] GO:0006468 [protein phosphorylation] GO:0033867 [Fas-activated serine/threonine kinase activity] GO:0043484 [regulation of RNA splicing] GO:0097190 [apoptotic signaling pathway] Show all	549 aa 61.1 kDa	No	0
FASTK-006 ENSP00000324817 ENST00000353841	Q14296 [Direct mapping] Fas-activated serine/threonine kinase A0A090N8I0 [Target identity:100%; Query identity:100%] FAST kinase Show all	Enzymes ENZYME proteins Transferases Kinases Atypical kinases THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0033867 [Fas-activated serine/threonine kinase activity] GO:0043484 [regulation of RNA splicing] GO:0097190 [apoptotic signaling pathway] Show all	408 aa 45.9 kDa	No	0
FASTK-201 ENSP00000444498 ENST00000540185	G3V1R6 [Direct mapping] Fas-activated serine/threonine kinase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0006468 [protein phosphorylation] Show all	465 aa 51.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.