Cell atlas - LETM2 - The Human Protein Atlas

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LETM2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleus

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LETM2
Gene description	Leucine zipper-EF-hand containing transmembrane protein 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleus. In addition localized to the cytosol & nuclear bodies.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleus (approved)
Additional location	In addition localized to the Nuclear bodies (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA025032
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleus. In addition localized to the cytosol & nuclear bodies.

Main location

Nucleus (approved)

Additional location

Nuclear bodies (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA025032	A-431	Nucleoplasm
	HPA025032	A-431	Nuclear bodies
	HPA025032	U-2 OS	Nucleus	Intensity	Intensity
	HPA025032	U-2 OS	Cytosol
	HPA025032	U-251 MG	Nucleoplasm
			Nuclear bodies
			Cytosol

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA025032	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. LETM2 is mostly expressed during S and/or G2, and during Mitosis.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nucleus

GENE INFORMATION
Gene name	LETM2 (HGNC Symbol)
Synonyms	FLJ25409
Description	Leucine zipper-EF-hand containing transmembrane protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38386207 - 38409527
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165046 (version 83.38)
Entrez gene	137994
UniProt	Q2VYF4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2VYF4
Antibodypedia	LETM2 antibodies

PROTEIN BROWSER

LETM2-001	LETM2-002	LETM2-003	LETM2-007	LETM2-009	LETM2-012	LETM2-013	LETM2-014	LETM2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LETM2-001 ENSP00000297720 ENST00000297720	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	396 aa 44.9 kDa	No	0
LETM2-002 ENSP00000429269 ENST00000519476	A8K1M9 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial; cDNA FLJ76602 Show all	Predicted intracellular proteins Show all		173 aa 20.1 kDa	No	0
LETM2-003 ENSP00000428765 ENST00000523983	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	444 aa 50.6 kDa	No	1
LETM2-007 ENSP00000434867 ENST00000527710	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	277 aa 30.9 kDa	No	0
LETM2-009 ENSP00000432607 ENST00000527175	H0YCZ8 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all		86 aa 9 kDa	No	0
LETM2-012 ENSP00000432080 ENST00000527334	E9PIC7 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all		116 aa 13 kDa	No	0
LETM2-013 ENSP00000369291 ENST00000379957	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	491 aa 55.9 kDa	No	1
LETM2-014 ENSP00000432955 ENST00000526356	E9PN52 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all		142 aa 16.4 kDa	No	0
LETM2-015 ENSP00000431211 ENST00000524874	E9PMA4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all		443 aa 50.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.