Expression of LETM2 in cancer - Summary - The Human Protein Atlas

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LETM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LETM2
Gene description	Leucine zipper-EF-hand containing transmembrane protein 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA025032 , HPA053676
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025032	HPA053676

GENE INFORMATION
Gene name	LETM2 (HGNC Symbol)
Synonyms	FLJ25409
Description	Leucine zipper-EF-hand containing transmembrane protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	p11.23
Chromosome location (bp)	38386207 - 38409527
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165046 (version 83.38)
Entrez gene	137994
UniProt	Q2VYF4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q2VYF4
Antibodypedia	LETM2 antibodies

PROTEIN BROWSER

LETM2-001	LETM2-002	LETM2-003	LETM2-007	LETM2-009	LETM2-012	LETM2-013	LETM2-014	LETM2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LETM2-001 ENSP00000297720 ENST00000297720	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	396 aa 44.9 kDa	No	0
LETM2-002 ENSP00000429269 ENST00000519476	A8K1M9 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial; cDNA FLJ76602 Show all	Predicted intracellular proteins Show all		173 aa 20.1 kDa	No	0
LETM2-003 ENSP00000428765 ENST00000523983	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	444 aa 50.6 kDa	No	1
LETM2-007 ENSP00000434867 ENST00000527710	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	277 aa 30.9 kDa	No	0
LETM2-009 ENSP00000432607 ENST00000527175	H0YCZ8 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all		86 aa 9 kDa	No	0
LETM2-012 ENSP00000432080 ENST00000527334	E9PIC7 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all		116 aa 13 kDa	No	0
LETM2-013 ENSP00000369291 ENST00000379957	Q2VYF4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005743 [mitochondrial inner membrane] GO:0016021 [integral component of membrane] Show all	491 aa 55.9 kDa	No	1
LETM2-014 ENSP00000432955 ENST00000526356	E9PN52 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	Predicted intracellular proteins Show all		142 aa 16.4 kDa	No	0
LETM2-015 ENSP00000431211 ENST00000524874	E9PMA4 [Direct mapping] LETM1 domain-containing protein LETM2, mitochondrial Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all		443 aa 50.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.