Cell atlas - ALDH1A1 - The Human Protein Atlas

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ALDH1A1

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ALDH1A1
Gene description	Aldehyde dehydrogenase 1 family, member A1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (A549, Hep G2, RPTEC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (validated)

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA002123
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (A549, Hep G2, RPTEC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA002123	A549	Cytosol
	HPA002123	Hep G2	Cytosol

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA002123	BJ	Image	Expression of ALDH1A1 is completely lost after the introduction of telomerase whereas primary BJ cells show cytoplasmic expression of ALDH1A1.
	HPA002123	BJ hTERT+	Image	Expression of ALDH1A1 is completely lost after the introduction of telomerase whereas primary BJ cells show cytoplasmic expression of ALDH1A1.
	HPA002123	BJ hTERT+ SV40 Large T+	Image	Expression of ALDH1A1 is completely lost after the introduction of telomerase whereas primary BJ cells show cytoplasmic expression of ALDH1A1.
	HPA002123	BJ hTERT+ SV40 Large T+ RasG12V	Image	Expression of ALDH1A1 is completely lost after the introduction of telomerase whereas primary BJ cells show cytoplasmic expression of ALDH1A1.

GENE INFORMATION
Gene name	ALDH1A1 (HGNC Symbol)
Synonyms	ALDH1, PUMB1, RALDH1
Description	Aldehyde dehydrogenase 1 family, member A1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	72900662 - 73080442
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165092 (version 83.38)
Entrez gene	216
UniProt	P00352 (UniProt - Evidence at protein level)
neXtProt	NX_P00352
Antibodypedia	ALDH1A1 antibodies

PROTEIN BROWSER

ALDH1A1-001	ALDH1A1-002	ALDH1A1-005	ALDH1A1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH1A1-001 ENSP00000297785 ENST00000297785	P00352 [Direct mapping] Retinal dehydrogenase 1 V9HW83 [Target identity:100%; Query identity:100%] Aldehyde dehydrogenase 1 family, member A1, isoform CRA_a; Epididymis luminal protein 12; Epididymis secretory sperm binding protein Li 53e Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0004029 [aldehyde dehydrogenase (NAD) activity] GO:0005096 [GTPase activator activity] GO:0005497 [androgen binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006069 [ethanol oxidation] GO:0006081 [cellular aldehyde metabolic process] GO:0006805 [xenobiotic metabolic process] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0042572 [retinol metabolic process] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	501 aa 54.9 kDa	No	0
ALDH1A1-002 ENSP00000401361 ENST00000446946	Q5SYQ7 [Direct mapping] Retinal dehydrogenase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0055114 [oxidation-reduction process] Show all	203 aa 22.7 kDa	No	0
ALDH1A1-005 ENSP00000366138 ENST00000376939	Q5SYQ9 [Direct mapping] Retinal dehydrogenase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0055114 [oxidation-reduction process] Show all	230 aa 25.3 kDa	No	0
ALDH1A1-006 ENSP00000388026 ENST00000419959	Q5SYQ8 [Direct mapping] Retinal dehydrogenase 1 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001758 [retinal dehydrogenase activity] GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity] GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity] GO:0055114 [oxidation-reduction process] Show all	238 aa 26.1 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.