Fields »
ABOUT
HELP
BLOG
ALDH1A1

GENERAL INFORMATION

Gene name

 ALDH1A1

Gene description

 Aldehyde dehydrogenase 1 family, member A1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in selected tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA002123 , CAB020690
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ALDH1A1 (HGNC Symbol)

Synonyms

 ALDH1, PUMB1, RALDH1

Description

 Aldehyde dehydrogenase 1 family, member A1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

Chromosome

 9

Cytoband

 q21.13

Chromosome location (bp)

 72900662 - 73080442

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165092 (version 83.38)

Entrez gene

 216

UniProt

 P00352 (UniProt - Evidence at protein level)

neXtProt

 NX_P00352

Antibodypedia

 ALDH1A1 antibodies

PROTEIN BROWSER
ALDH1A1-001
ALDH1A1-002
ALDH1A1-005
ALDH1A1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH1A1-001
ENSP00000297785
ENST00000297785
P00352 [Direct mapping]
Retinal dehydrogenase 1
V9HW83 [Target identity:100%; Query identity:100%]
Aldehyde dehydrogenase 1 family, member A1, isoform CRA_a; Epididymis luminal protein 12; Epididymis secretory sperm binding protein Li 53e
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0005096 [GTPase activator activity]
GO:0005497 [androgen binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006069 [ethanol oxidation]
GO:0006081 [cellular aldehyde metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0042572 [retinol metabolic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 501 aa
54.9 kDa 		No 0
ALDH1A1-002
ENSP00000401361
ENST00000446946
Q5SYQ7 [Direct mapping]
Retinal dehydrogenase 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 203 aa
22.7 kDa 		No 0
ALDH1A1-005
ENSP00000366138
ENST00000376939
Q5SYQ9 [Direct mapping]
Retinal dehydrogenase 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 230 aa
25.3 kDa 		No 0
ALDH1A1-006
ENSP00000388026
ENST00000419959
Q5SYQ8 [Direct mapping]
Retinal dehydrogenase 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001758 [retinal dehydrogenase activity]
GO:0004028 [3-chloroallyl aldehyde dehydrogenase activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0018479 [benzaldehyde dehydrogenase (NAD+) activity]
GO:0055114 [oxidation-reduction process]
Show all
 238 aa
26.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.