Expression of TRPV6 in cancer - Summary

GENERAL INFORMATION
Gene name	TRPV6
Gene description	Transient receptor potential cation channel, subfamily V, member 6
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Cell line enhanced (HaCaT, RT4, SK-BR-3, T-47d)
HPA (normal tissue):	Tissue enhanced (prostate, salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in selected cell types, most abundant in decidual cells and endothelial cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA062864
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA062864

GENE INFORMATION
Gene name	TRPV6 (HGNC Symbol)
Synonyms	CaT1, ECAC2
Description	Transient receptor potential cation channel, subfamily V, member 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015]
Chromosome	7
Cytoband	q34
Chromosome location (bp)	142871203 - 142885762
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165125 (version 83.38)
Entrez gene	55503
UniProt	Q9H1D0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H1D0
Antibodypedia	TRPV6 antibodies

PROTEIN BROWSER

TRPV6-001	TRPV6-006	TRPV6-007	TRPV6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPV6-001 ENSP00000352358 ENST00000359396	Q9H1D0 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Transporters Transporter channels and pores Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017158 [regulation of calcium ion-dependent exocytosis] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070588 [calcium ion transmembrane transport] Show all	765 aa 87.3 kDa	No	6
TRPV6-006 ENSP00000411100 ENST00000436401	C9J9W0 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	122 aa 13.7 kDa	No	3
TRPV6-007 ENSP00000415917 ENST00000431833	C9JHY1 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Predicted intracellular proteins Show all	GO:0005262 [calcium channel activity] GO:0016021 [integral component of membrane] GO:0070588 [calcium ion transmembrane transport] Show all	56 aa 6 kDa	No	0
TRPV6-201 ENSP00000479084 ENST00000463646	A0A087WV12 [Direct mapping] Transient receptor potential cation channel subfamily V member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	526 aa 60.4 kDa	No	6