Cell atlas - CLDN3 - The Human Protein Atlas

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CLDN3

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CLDN3
Gene description	Claudin 3
Protein class	Cancer-related genes Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions.
RNA cell category	Cell line enhanced (MCF7, T-47d, SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA014361
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7, T-47d, SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions.

Main location

Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA014361	MCF7	Cell Junctions
	HPA014361	U-2 OS	No staining

GENE INFORMATION
Gene name	CLDN3 (HGNC Symbol)
Synonyms	C7orf1, CPE-R2, CPETR2, HRVP1, RVP1
Description	Claudin 3 (HGNC Symbol)
Entrez gene summary	Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	73768997 - 73770270
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165215 (version 83.38)
Entrez gene	1365
UniProt	O15551 (UniProt - Evidence at protein level)
neXtProt	NX_O15551
Antibodypedia	CLDN3 antibodies

PROTEIN BROWSER

CLDN3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN3-001 ENSP00000378577 ENST00000395145	O15551 [Direct mapping] Claudin-3 Q75L79 [Target identity:100%; Query identity:100%] Claudin Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001666 [response to hypoxia] GO:0003382 [epithelial cell morphogenesis] GO:0004888 [transmembrane signaling receptor activity] GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0005923 [bicellular tight junction] GO:0007165 [signal transduction] GO:0016021 [integral component of membrane] GO:0016327 [apicolateral plasma membrane] GO:0016328 [lateral plasma membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0051260 [protein homooligomerization] GO:0051291 [protein heterooligomerization] GO:0070062 [extracellular exosome] GO:0070830 [bicellular tight junction assembly] Show all	220 aa 23.3 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.