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CLDN3

GENERAL INFORMATION

Gene name

 CLDN3

Gene description

 Claudin 3

Protein class

 Cancer-related genes
Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (colon, small intestine)
GTEx:Tissue enhanced (colon, small intestine)
FANTOM5:Tissue enhanced (colon, small intestine, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous expression in several tissues, including gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA014361 , CAB002702
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine, thyroid gland)

GENE INFORMATION

Gene name

 CLDN3 (HGNC Symbol)

Synonyms

 C7orf1, CPE-R2, CPETR2, HRVP1, RVP1

Description

 Claudin 3 (HGNC Symbol)

Entrez gene summary

 Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 73768997 - 73770270

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165215 (version 83.38)

Entrez gene

 1365

UniProt

 O15551 (UniProt - Evidence at protein level)

neXtProt

 NX_O15551

Antibodypedia

 CLDN3 antibodies

PROTEIN BROWSER
CLDN3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLDN3-001
ENSP00000378577
ENST00000395145
O15551 [Direct mapping]
Claudin-3
Q75L79 [Target identity:100%; Query identity:100%]
Claudin
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001666 [response to hypoxia]
GO:0003382 [epithelial cell morphogenesis]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0005923 [bicellular tight junction]
GO:0007165 [signal transduction]
GO:0016021 [integral component of membrane]
GO:0016327 [apicolateral plasma membrane]
GO:0016328 [lateral plasma membrane]
GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules]
GO:0042802 [identical protein binding]
GO:0051260 [protein homooligomerization]
GO:0051291 [protein heterooligomerization]
GO:0070062 [extracellular exosome]
GO:0070830 [bicellular tight junction assembly]
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 220 aa
23.3 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.