Expression of WNK2 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	WNK2
Gene description	WNK lysine deficient protein kinase 2
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Hep G2, SCLC-21H)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues most abundant in salivary gland, glandular cells in the gastrointestinal tract, bile ducts, exocrine glandular cells and placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 3 antibodies. HPA015555 , HPA016519 , CAB017813
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA015555	HPA016519	CAB017813

GENE INFORMATION
Gene name	WNK2 (HGNC Symbol)
Synonyms	KIAA1760, NY-CO-43, PRKWNK2, SDCCAG43
Description	WNK lysine deficient protein kinase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Chromosome	9
Cytoband	q22.31
Chromosome location (bp)	93184916 - 93320572
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165238 (version 83.38)
Entrez gene	65268
UniProt	Q9Y3S1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3S1
Antibodypedia	WNK2 antibodies

PROTEIN BROWSER

WNK2-001	WNK2-002	WNK2-009	WNK2-010	WNK2-011	WNK2-014	WNK2-201	WNK2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WNK2-001 ENSP00000297954 ENST00000297954	Q9Y3S1 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0008285 [negative regulation of cell proliferation] GO:0035556 [intracellular signal transduction] GO:0046777 [protein autophosphorylation] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:2000021 [regulation of ion homeostasis] GO:2000651 [positive regulation of sodium ion transmembrane transporter activity] Show all	2297 aa 242.7 kDa	No	0
WNK2-002 ENSP00000390441 ENST00000448251	H0Y493 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		1014 aa 106.1 kDa	No	0
WNK2-009 ENSP00000415038 ENST00000432730	H0Y7T5 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	2220 aa 234.5 kDa	No	0
WNK2-010 ENSP00000414622 ENST00000411624	H0Y7R3 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	1773 aa 185.8 kDa	No	0
WNK2-011 ENSP00000412465 ENST00000448039	A6PVV2 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	790 aa 85.9 kDa	No	0
WNK2-014 ENSP00000413325 ENST00000453718	H0Y7J9 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		646 aa 67.4 kDa	No	0
WNK2-201 ENSP00000378860 ENST00000395477	F8W9F9 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] Show all	2217 aa 234.4 kDa	No	0
WNK2-202 ENSP00000411181 ENST00000427277	E9PCD1 [Direct mapping] Serine/threonine-protein kinase WNK2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	363 aa 38.6 kDa	No	0