Expression of AQP7 in cancer - Summary - The Human Protein Atlas

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AQP7

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	AQP7
Gene description	Aquaporin 7
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, ASC TERT1, CACO-2, Hep G2, TIME)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	AQP7 (HGNC Symbol)
Synonyms	AQP7L, AQP9, AQPap
Description	Aquaporin 7 (HGNC Symbol)
Entrez gene summary	Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin 7 facilitates water, glycerol and urea transport. It may play an important role in sperm function. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	33383179 - 33402682
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165269 (version 83.38)
Entrez gene	364
UniProt	O14520 (UniProt - Evidence at protein level)
neXtProt	NX_O14520
Antibodypedia	AQP7 antibodies

PROTEIN BROWSER

AQP7-001	AQP7-003	AQP7-004	AQP7-006	AQP7-007	AQP7-009	AQP7-014	AQP7-015	AQP7-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AQP7-001 ENSP00000368821 ENST00000379507	Q5T5M1 [Direct mapping] Aquaporin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005623 [cell] GO:0006810 [transport] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	341 aa 37 kDa	No	6
AQP7-003 ENSP00000368820 ENST00000379506	Q5T5M0 [Direct mapping] Aquaporin-7; cDNA FLJ52444, highly similar to Aquaporin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005623 [cell] GO:0006810 [transport] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	256 aa 27.9 kDa	No	5
AQP7-004 ENSP00000396111 ENST00000377425	Q6P5T0 [Direct mapping] AQP7 protein; Aquaporin 7, isoform CRA_b; Aquaporin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005623 [cell] GO:0006810 [transport] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	216 aa 23.3 kDa	No	4
AQP7-006 ENSP00000297988 ENST00000297988	O14520 [Direct mapping] Aquaporin-7 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0006833 [water transport] GO:0007588 [excretion] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	342 aa 37.2 kDa	No	6
AQP7-007 ENSP00000410138 ENST00000439678	Q5T5L3 [Direct mapping] Aquaporin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005623 [cell] GO:0006810 [transport] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	170 aa 18.6 kDa	No	3
AQP7-009 ENSP00000485332 ENST00000624075	B7Z4U2 [Direct mapping] Aquaporin-7; cDNA FLJ60727, highly similar to Aquaporin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005623 [cell] GO:0006810 [transport] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	257 aa 28.1 kDa	No	5
AQP7-014 ENSP00000412868 ENST00000447660	O14520 [Direct mapping] Aquaporin-7 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005911 [cell-cell junction] GO:0006091 [generation of precursor metabolites and energy] GO:0006810 [transport] GO:0006833 [water transport] GO:0007588 [excretion] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0015250 [water channel activity] GO:0015254 [glycerol channel activity] GO:0015793 [glycerol transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	165 aa 18 kDa	No	3
AQP7-015 ENSP00000485081 ENST00000625109	A0A096LNK2 [Direct mapping] Aquaporin-7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005623 [cell] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	80 aa 9 kDa	No	1
AQP7-017 ENSP00000485246 ENST00000625032	A0A096LNV7 [Direct mapping] Aquaporin-7 Show all	Predicted intracellular proteins Show all	GO:0005623 [cell] GO:0009992 [cellular water homeostasis] GO:0015204 [urea transmembrane transporter activity] GO:0034220 [ion transmembrane transport] GO:0071918 [urea transmembrane transport] Show all	50 aa 5.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.