Cell atlas - ARHGAP12 - The Human Protein Atlas

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ARHGAP12

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ARHGAP12
Gene description	Rho GTPase activating protein 12
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ARHGAP12 (HGNC Symbol)
Synonyms	FLJ10971, FLJ20737, FLJ21785
Description	Rho GTPase activating protein 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	10
Cytoband	p11.22
Chromosome location (bp)	31805404 - 31928876
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165322 (version 83.38)
Entrez gene	94134
UniProt	Q8IWW6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWW6
Antibodypedia	ARHGAP12 antibodies

PROTEIN BROWSER

ARHGAP12-001	ARHGAP12-005	ARHGAP12-008	ARHGAP12-009	ARHGAP12-201	ARHGAP12-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ARHGAP12-001 ENSP00000310984 ENST00000311380	Q8IWW6 [Direct mapping] Rho GTPase-activating protein 12 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002011 [morphogenesis of an epithelial sheet] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	794 aa 90.4 kDa	No	0
ARHGAP12-005 ENSP00000398050 ENST00000454919	H0Y5D8 [Direct mapping] Rho GTPase-activating protein 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	196 aa 22.3 kDa	No	0
ARHGAP12-008 ENSP00000364399 ENST00000375250	Q8IWW6 [Direct mapping] Rho GTPase-activating protein 12 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002011 [morphogenesis of an epithelial sheet] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	816 aa 93.1 kDa	No	0
ARHGAP12-009 ENSP00000345808 ENST00000344936	Q8IWW6 [Direct mapping] Rho GTPase-activating protein 12 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002011 [morphogenesis of an epithelial sheet] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	846 aa 96.3 kDa	No	0
ARHGAP12-201 ENSP00000364394 ENST00000375245	Q1RLN5 [Direct mapping] ARHGAP12 protein; Rho GTPase-activating protein 12 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007165 [signal transduction] Show all	799 aa 90.9 kDa	No	0
ARHGAP12-202 ENSP00000379448 ENST00000396144	Q8IWW6 [Direct mapping] Rho GTPase-activating protein 12 Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002011 [morphogenesis of an epithelial sheet] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	841 aa 95.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.