Fields »
ABOUT
HELP
BLOG
ARHGAP12

GENERAL INFORMATION

Gene name

 ARHGAP12

Gene description

 Rho GTPase activating protein 12

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA000412
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and glioma (favourable).
Renal cancer p<0.001
Glioma p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000412

GENE INFORMATION

Gene name

 ARHGAP12 (HGNC Symbol)

Synonyms

 FLJ10971, FLJ20737, FLJ21785

Description

 Rho GTPase activating protein 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Chromosome

 10

Cytoband

 p11.22

Chromosome location (bp)

 31805404 - 31928876

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165322 (version 83.38)

Entrez gene

 94134

UniProt

 Q8IWW6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IWW6

Antibodypedia

 ARHGAP12 antibodies

PROTEIN BROWSER
ARHGAP12-001
ARHGAP12-005
ARHGAP12-008
ARHGAP12-009
ARHGAP12-201
ARHGAP12-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGAP12-001
ENSP00000310984
ENST00000311380
Q8IWW6 [Direct mapping]
Rho GTPase-activating protein 12
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 794 aa
90.4 kDa 		No 0
ARHGAP12-005
ENSP00000398050
ENST00000454919
H0Y5D8 [Direct mapping]
Rho GTPase-activating protein 12
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 196 aa
22.3 kDa 		No 0
ARHGAP12-008
ENSP00000364399
ENST00000375250
Q8IWW6 [Direct mapping]
Rho GTPase-activating protein 12
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 816 aa
93.1 kDa 		No 0
ARHGAP12-009
ENSP00000345808
ENST00000344936
Q8IWW6 [Direct mapping]
Rho GTPase-activating protein 12
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 846 aa
96.3 kDa 		No 0
ARHGAP12-201
ENSP00000364394
ENST00000375245
Q1RLN5 [Direct mapping]
ARHGAP12 protein; Rho GTPase-activating protein 12
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
Show all
 799 aa
90.9 kDa 		No 0
ARHGAP12-202
ENSP00000379448
ENST00000396144
Q8IWW6 [Direct mapping]
Rho GTPase-activating protein 12
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002011 [morphogenesis of an epithelial sheet]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0043547 [positive regulation of GTPase activity]
GO:0051056 [regulation of small GTPase mediated signal transduction]
Show all
 841 aa
95.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.