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SLC7A3

GENERAL INFORMATION

Gene name

 SLC7A3

Gene description

 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enriched (NTERA-2)
HPA (normal tissue):Tissue enhanced (endometrium, prostate, seminal vesicle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous and cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003629
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA003629

GENE INFORMATION

Gene name

 SLC7A3 (HGNC Symbol)

Synonyms

 ATRC3, CAT-3, FLJ14541

Description

 Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

Chromosome

 X

Cytoband

 q13.1

Chromosome location (bp)

 70925582 - 70931125

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165349 (version 83.38)

Entrez gene

 84889

UniProt

 Q8WY07 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WY07

Antibodypedia

 SLC7A3 antibodies

PROTEIN BROWSER
SLC7A3-001
SLC7A3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC7A3-001
ENSP00000363417
ENST00000374299
Q8WY07 [Direct mapping]
Cationic amino acid transporter 3
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0000064 [L-ornithine transmembrane transporter activity]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015174 [basic amino acid transmembrane transporter activity]
GO:0015181 [arginine transmembrane transporter activity]
GO:0015189 [L-lysine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015809 [arginine transport]
GO:0015819 [lysine transport]
GO:0015822 [ornithine transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032006 [regulation of TOR signaling]
GO:0055085 [transmembrane transport]
GO:0097638 [L-arginine import across plasma membrane]
GO:1903352 [L-ornithine transmembrane transport]
GO:1903401 [L-lysine transmembrane transport]
GO:1990822 [basic amino acid transmembrane transport]
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 619 aa
67.2 kDa 		No >9
SLC7A3-002
ENSP00000298085
ENST00000298085
Q8WY07 [Direct mapping]
Cationic amino acid transporter 3
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000064 [L-ornithine transmembrane transporter activity]
GO:0003333 [amino acid transmembrane transport]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015181 [arginine transmembrane transporter activity]
GO:0015189 [L-lysine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
GO:0097638 [L-arginine import across plasma membrane]
GO:1903352 [L-ornithine transmembrane transport]
GO:1903401 [L-lysine transmembrane transport]
Show all
 619 aa
67.2 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.