Cell atlas - CLDN2 - The Human Protein Atlas

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CLDN2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Nucleoplasm

Human cell
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CLDN2
Gene description	Claudin 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions & nucleoplasm.
RNA cell category	Group enriched (RPTEC TERT1, A549, CACO-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Cell Junctions (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA051548
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, A549, CACO-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions & nucleoplasm.

Main location

Nucleoplasm (approved), Cell Junctions (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA051548	A549	Nucleoplasm
	HPA051548	CACO-2	Nucleoplasm
	HPA051548	CACO-2	Cell Junctions
	HPA051548	U-2 OS	No staining

MOUSE CELLS

Main location

Not available

Mouse gene

ENSMUSG00000047230 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA051548	NIH 3T3	No staining

GENE INFORMATION
Gene name	CLDN2
Synonyms
Description	Claudin 2 (HGNC Symbol)
Entrez gene summary	This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
Chromosome	X
Cytoband	q22.3
Chromosome location (bp)	106900164 - 106930861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165376 (version 83.38)
Entrez gene	9075
UniProt	P57739 (UniProt - Evidence at protein level)
neXtProt	NX_P57739
Antibodypedia	CLDN2 antibodies

PROTEIN BROWSER

CLDN2-001	CLDN2-201	CLDN2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN2-001 ENSP00000336571 ENST00000336803	P57739 [Direct mapping] Claudin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0070062 [extracellular exosome] Show all	230 aa 24.5 kDa	No	4
CLDN2-201 ENSP00000443230 ENST00000540876	P57739 [Direct mapping] Claudin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0070062 [extracellular exosome] Show all	230 aa 24.5 kDa	No	4
CLDN2-202 ENSP00000441283 ENST00000541806	P57739 [Direct mapping] Claudin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0070062 [extracellular exosome] Show all	230 aa 24.5 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.