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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MBL2
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MBL2

Gene description

Mannose-binding lectin (protein C) 2, soluble

Protein class

Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly specific cytoplasmic expression in liver with distinct positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA002027 , CAB016782
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA002027
CAB016782

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues were negative. Strong cytoplasmic immunoreactivity was observed in most liver cancer.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas exhibited strong cytoplasmic immunoreactivity. Remaining cancer cells were in general negative.

GENE INFORMATION

Gene name

MBL2 (HGNC Symbol)

Synonyms

COLEC1, MBL

Description

Mannose-binding lectin (protein C) 2, soluble (HGNC Symbol)

Entrez gene summary

This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

q21.1

Chromosome location (bp)

52765380 - 52771700

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000165471 (version 83.38)

Entrez gene

4153

UniProt

P11226 (UniProt - Evidence at protein level)

neXtProt

NX_P11226

Antibodypedia

MBL2 antibodies

PROTEIN BROWSER

MBL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MBL2-001
ENSP00000363079
ENST00000373968
P11226 [Direct mapping]
Mannose-binding protein C
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001867 [complement activation, lectin pathway]
GO:0005102 [receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0006979 [response to oxidative stress]
GO:0008228 [opsonization]
GO:0009986 [cell surface]
GO:0042742 [defense response to bacterium]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0048525 [negative regulation of viral process]
GO:0050766 [positive regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051873 [killing by host of symbiont cells]
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248 aa
26.1 kDa
Yes 0

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