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MBL2

GENERAL INFORMATION

Gene name

 MBL2

Gene description

 Mannose-binding lectin (protein C) 2, soluble

Protein class

 Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (liver)
GTEx:Tissue enriched (liver)
FANTOM5:Tissue enriched (liver)

Protein evidence

 Evidence at protein level

Protein expression

 Highly specific cytoplasmic expression in liver with distinct positivity in plasma.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA002027 , CAB016782
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)

GENE INFORMATION

Gene name

 MBL2 (HGNC Symbol)

Synonyms

 COLEC1, MBL

Description

 Mannose-binding lectin (protein C) 2, soluble (HGNC Symbol)

Entrez gene summary

 This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q21.1

Chromosome location (bp)

 52765380 - 52771700

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165471 (version 83.38)

Entrez gene

 4153

UniProt

 P11226 (UniProt - Evidence at protein level)

neXtProt

 NX_P11226

Antibodypedia

 MBL2 antibodies

PROTEIN BROWSER
MBL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MBL2-001
ENSP00000363079
ENST00000373968
P11226 [Direct mapping]
Mannose-binding protein C
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001867 [complement activation, lectin pathway]
GO:0005102 [receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005537 [mannose binding]
GO:0005576 [extracellular region]
GO:0005581 [collagen trimer]
GO:0005615 [extracellular space]
GO:0006953 [acute-phase response]
GO:0006956 [complement activation]
GO:0006958 [complement activation, classical pathway]
GO:0006979 [response to oxidative stress]
GO:0008228 [opsonization]
GO:0009986 [cell surface]
GO:0042742 [defense response to bacterium]
GO:0044130 [negative regulation of growth of symbiont in host]
GO:0045087 [innate immune response]
GO:0048306 [calcium-dependent protein binding]
GO:0048525 [negative regulation of viral process]
GO:0050766 [positive regulation of phagocytosis]
GO:0050830 [defense response to Gram-positive bacterium]
GO:0051873 [killing by host of symbiont cells]
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 248 aa
26.1 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.