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SSX5

GENERAL INFORMATION

Gene name

 SSX5

Gene description

 Synovial sarcoma, X breakpoint 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Cell line enriched (BEWO)
HPA (normal tissue):Tissue enhanced (thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA045683
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045683

GENE INFORMATION

Gene name

 SSX5

Synonyms

Description

 Synovial sarcoma, X breakpoint 5 (HGNC Symbol)

Entrez gene summary

 The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 48186220 - 48277578

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165583 (version 83.38)

Entrez gene

 6758

UniProt

 O60225 (UniProt - Evidence at protein level)

neXtProt

 NX_O60225

Antibodypedia

 SSX5 antibodies

PROTEIN BROWSER
SSX5-001
SSX5-002
SSX5-003
SSX5-201
SSX5-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SSX5-001
ENSP00000312415
ENST00000311798
O60225 [Direct mapping]
Protein SSX5
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 229 aa
26.3 kDa 		No 0
SSX5-002
ENSP00000366122
ENST00000376923
O60225 [Direct mapping]
Protein SSX5
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 188 aa
21.7 kDa 		No 0
SSX5-003
ENSP00000385051
ENST00000403001
Q5JQ63 [Direct mapping]
Protein SSX5; Synovial sarcoma, X breakpoint 5
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Predicted intracellular proteins
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GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
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 128 aa
14.4 kDa 		No 0
SSX5-201
ENSP00000290558
ENST00000347757
O60225 [Direct mapping]
Protein SSX5
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
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 188 aa
21.7 kDa 		No 0
SSX5-202
ENSP00000482104
ENST00000613884
A0A087WYU7 [Direct mapping]
Protein SSX5
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 188 aa
21.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.