Tissue expression of SSX5 - Summary - The Human Protein Atlas

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SSX5

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SSX5
Gene description	Synovial sarcoma, X breakpoint 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (thyroid gland)
GTEx:	Tissue enhanced (testis)
FANTOM5:	Not detected

Protein evidence

Evidence at protein level

Protein expression

Estimation of protein expression could not be performed. View primary data.

DATA RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Uncertain based on 1 antibody. HPA045683
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

N/A

Caudate

N/A

N/A

Cerebellum

N/A

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

N/A

Bronchus

N/A

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

N/A

Skin

N/A

Skin

N/A

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Not detected

GENE INFORMATION
Gene name	SSX5
Synonyms
Description	Synovial sarcoma, X breakpoint 5 (HGNC Symbol)
Entrez gene summary	The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. While some of the related SSX genes are involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas, this gene does not appear to be involved in such translocations. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48186220 - 48277578
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165583 (version 83.38)
Entrez gene	6758
UniProt	O60225 (UniProt - Evidence at protein level)
neXtProt	NX_O60225
Antibodypedia	SSX5 antibodies

PROTEIN BROWSER

SSX5-001	SSX5-002	SSX5-003	SSX5-201	SSX5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SSX5-001 ENSP00000312415 ENST00000311798	O60225 [Direct mapping] Protein SSX5 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	229 aa 26.3 kDa	No	0
SSX5-002 ENSP00000366122 ENST00000376923	O60225 [Direct mapping] Protein SSX5 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	188 aa 21.7 kDa	No	0
SSX5-003 ENSP00000385051 ENST00000403001	Q5JQ63 [Direct mapping] Protein SSX5; Synovial sarcoma, X breakpoint 5 Show all	Predicted intracellular proteins Show all	GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	128 aa 14.4 kDa	No	0
SSX5-201 ENSP00000290558 ENST00000347757	O60225 [Direct mapping] Protein SSX5 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	188 aa 21.7 kDa	No	0
SSX5-202 ENSP00000482104 ENST00000613884	A0A087WYU7 [Direct mapping] Protein SSX5 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	188 aa 21.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.