Cell atlas - FAM69B - The Human Protein Atlas

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FAM69B

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nuclear bodies
	Nucleus
	Vesicles

Human cell
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	FAM69B
Gene description	Family with sequence similarity 69, member B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the nucleus & vesicles.
RNA cell category	Cell line enhanced (HUVEC TERT2, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (approved)
Additional location	In addition localized to the Nucleus (approved), Vesicles (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA054443
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HUVEC TERT2, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the nucleus & vesicles.

Main location

Nuclear bodies (approved)

Additional location

Nucleus (approved), Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA054443	CACO-2	Nucleoplasm
			Nuclear bodies	Spatial
			Vesicles	Spatial
	HPA054443	HEK 293	Nuclear bodies	Intensity
	HPA054443	U-2 OS	Nucleus
	HPA054443	U-2 OS	Nuclear bodies	Intensity

GENE INFORMATION
Gene name	FAM69B (HGNC Symbol)
Synonyms	C9orf136, MGC20262
Description	Family with sequence similarity 69, member B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136712570 - 136724050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165716 (version 83.38)
Entrez gene	138311
UniProt	Q5VUD6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VUD6
Antibodypedia	FAM69B antibodies

PROTEIN BROWSER

FAM69B-001	FAM69B-002	FAM69B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM69B-001 ENSP00000360757 ENST00000371692	Q5VUD6 [Direct mapping] Protein FAM69B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	431 aa 48.6 kDa	Yes	1
FAM69B-002 ENSP00000360756 ENST00000371691	Q5VUD6 [Direct mapping] Protein FAM69B A0A024R8I5 [Target identity:100%; Query identity:100%] Family with sequence similarity 69, member B, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	344 aa 38.5 kDa	No	0
FAM69B-201 ENSP00000479422 ENST00000617017	A0A087WVG3 [Direct mapping] Protein FAM69B Show all	Predicted intracellular proteins Show all		266 aa 29.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.