Expression of FAM69B in cancer - Summary - The Human Protein Atlas

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FAM69B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM69B
Gene description	Family with sequence similarity 69, member B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21, HUVEC TERT2)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. GTEx characterization data supports antibody staining in cerebellum.
Reliability score	Uncertain based on 1 antibody. HPA046812
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and pancreatic cancer (favourable).
Colorectal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046812

GENE INFORMATION
Gene name	FAM69B (HGNC Symbol)
Synonyms	C9orf136, MGC20262
Description	Family with sequence similarity 69, member B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. [provided by RefSeq, Nov 2011]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	136712570 - 136724050
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165716 (version 83.38)
Entrez gene	138311
UniProt	Q5VUD6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VUD6
Antibodypedia	FAM69B antibodies

PROTEIN BROWSER

FAM69B-001	FAM69B-002	FAM69B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM69B-001 ENSP00000360757 ENST00000371692	Q5VUD6 [Direct mapping] Protein FAM69B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	431 aa 48.6 kDa	Yes	1
FAM69B-002 ENSP00000360756 ENST00000371691	Q5VUD6 [Direct mapping] Protein FAM69B A0A024R8I5 [Target identity:100%; Query identity:100%] Family with sequence similarity 69, member B, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] Show all	344 aa 38.5 kDa	No	0
FAM69B-201 ENSP00000479422 ENST00000617017	A0A087WVG3 [Direct mapping] Protein FAM69B Show all	Predicted intracellular proteins Show all		266 aa 29.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.