Expression of PRAP1 in cancer - Summary

GENERAL INFORMATION
Gene name	PRAP1
Gene description	Proline-rich acidic protein 1
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, liver cancer)
HPA (cell line):	Cell line enhanced (CACO-2, Hep G2)
HPA (normal tissue):	Group enriched (duodenum, liver, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in hepatocytes, intestine and a subset of cells in renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA035360 , HPA038713 , HPA052451
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, liver cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035360	HPA038713	HPA052451

GENE INFORMATION
Gene name	PRAP1 (HGNC Symbol)
Synonyms	UPA
Description	Proline-rich acidic protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	10
Cytoband	q26.3
Chromosome location (bp)	133309410 - 133352683
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165828 (version 83.38)
Entrez gene	118471
UniProt	Q96NZ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96NZ9
Antibodypedia	PRAP1 antibodies

PROTEIN BROWSER

PRAP1-001	PRAP1-002	PRAP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRAP1-001 ENSP00000416126 ENST00000433452	Q96NZ9 [Direct mapping] Proline-rich acidic protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	151 aa 17.2 kDa	Yes	0
PRAP1-002 ENSP00000486265 ENST00000463201	Q96NZ9 [Direct mapping] Proline-rich acidic protein 1 A6XND8 [Target identity:100%; Query identity:100%] Proline-rich acidic protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	142 aa 16.3 kDa	Yes	0
PRAP1-201 ENSP00000357542 ENST00000368554	H7BY64 [Direct mapping] Proline-rich acidic protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0046872 [metal ion binding] Show all	310 aa 35.2 kDa	No	1