Cell atlas - ISCA2 - The Human Protein Atlas

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ISCA2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	ISCA2
Gene description	Iron-sulfur cluster assembly 2
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	ISCA2 (HGNC Symbol)
Synonyms	HBLD1, ISA2
Description	Iron-sulfur cluster assembly 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	74493720 - 74497106
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000165898 (version 83.38)
Entrez gene	122961
UniProt	Q86U28 (UniProt - Evidence at protein level)
neXtProt	NX_Q86U28
Antibodypedia	ISCA2 antibodies

PROTEIN BROWSER

ISCA2-001	ISCA2-002	ISCA2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ISCA2-001 ENSP00000452007 ENST00000556816	Q86U28 [Direct mapping] Iron-sulfur cluster assembly 2 homolog, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006790 [sulfur compound metabolic process] GO:0008198 [ferrous iron binding] GO:0016226 [iron-sulfur cluster assembly] GO:0051536 [iron-sulfur cluster binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0097428 [protein maturation by iron-sulfur cluster transfer] Show all	154 aa 16.5 kDa	No	0
ISCA2-002 ENSP00000298818 ENST00000298818	J3QSS7 [Direct mapping] Iron-sulfur cluster assembly 2 homolog, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		108 aa 11.4 kDa	No	0
ISCA2-003 ENSP00000450523 ENST00000554924	Q86U28 [Direct mapping] Iron-sulfur cluster assembly 2 homolog, mitochondrial Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005759 [mitochondrial matrix] GO:0006790 [sulfur compound metabolic process] GO:0008198 [ferrous iron binding] GO:0016226 [iron-sulfur cluster assembly] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0097428 [protein maturation by iron-sulfur cluster transfer] Show all	60 aa 6.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.