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ISCA2

GENERAL INFORMATION

Gene name

 ISCA2

Gene description

 Iron-sulfur cluster assembly 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA030492
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ISCA2 (HGNC Symbol)

Synonyms

 HBLD1, ISA2

Description

 Iron-sulfur cluster assembly 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

Chromosome

 14

Cytoband

 q24.3

Chromosome location (bp)

 74493720 - 74497106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000165898 (version 83.38)

Entrez gene

 122961

UniProt

 Q86U28 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86U28

Antibodypedia

 ISCA2 antibodies

PROTEIN BROWSER
ISCA2-001
ISCA2-002
ISCA2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ISCA2-001
ENSP00000452007
ENST00000556816
Q86U28 [Direct mapping]
Iron-sulfur cluster assembly 2 homolog, mitochondrial
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006790 [sulfur compound metabolic process]
GO:0008198 [ferrous iron binding]
GO:0016226 [iron-sulfur cluster assembly]
GO:0051536 [iron-sulfur cluster binding]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0097428 [protein maturation by iron-sulfur cluster transfer]
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 154 aa
16.5 kDa 		No 0
ISCA2-002
ENSP00000298818
ENST00000298818
J3QSS7 [Direct mapping]
Iron-sulfur cluster assembly 2 homolog, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 108 aa
11.4 kDa 		No 0
ISCA2-003
ENSP00000450523
ENST00000554924
Q86U28 [Direct mapping]
Iron-sulfur cluster assembly 2 homolog, mitochondrial
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005759 [mitochondrial matrix]
GO:0006790 [sulfur compound metabolic process]
GO:0008198 [ferrous iron binding]
GO:0016226 [iron-sulfur cluster assembly]
GO:0051537 [2 iron, 2 sulfur cluster binding]
GO:0051539 [4 iron, 4 sulfur cluster binding]
GO:0097428 [protein maturation by iron-sulfur cluster transfer]
Show all
 60 aa
6.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.