Expression of PASD1 in cancer - Summary - The Human Protein Atlas

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PASD1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PASD1
Gene description	PAS domain containing 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (BEWO, HMC-1, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective nuclear expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA011122 , HPA011152
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011122	HPA011152

GENE INFORMATION
Gene name	PASD1 (HGNC Symbol)
Synonyms	CT63
Description	PAS domain containing 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	151563622 - 151676739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166049 (version 83.38)
Entrez gene	139135
UniProt	Q8IV76 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IV76
Antibodypedia	PASD1 antibodies

PROTEIN BROWSER

PASD1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PASD1-001 ENSP00000359382 ENST00000370357	Q8IV76 [Direct mapping] Circadian clock protein PASD1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001223 [transcription coactivator binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0042754 [negative regulation of circadian rhythm] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0048511 [rhythmic process] GO:1990512 [Cry-Per complex] Show all	773 aa 87.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.