Cell atlas - ADAMTS15 - The Human Protein Atlas

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ADAMTS15

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	ADAMTS15
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 15
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (EFO-21, ASC TERT1)
Protein evidence	Evidence at transcript level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA042867
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (EFO-21, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA042867	A-431	Cytosol
	HPA042867	U-2 OS	Cytosol
	HPA042867	U-251 MG	No staining

GENE INFORMATION
Gene name	ADAMTS15
Synonyms
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 15 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	130448974 - 130476641
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000166106 (version 83.38)
Entrez gene	170689
UniProt	Q8TE58 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TE58
Antibodypedia	ADAMTS15 antibodies

PROTEIN BROWSER

ADAMTS15-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS15-001 ENSP00000299164 ENST00000299164	Q8TE58 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 15 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	950 aa 103.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.