Expression of ADAMTS15 in cancer - Summary - The Human Protein Atlas

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ADAMTS15

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAMTS15
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 15
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (ASC TERT1, EFO-21)
HPA (normal tissue):	Tissue enhanced (adipose tissue, placenta)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA042867
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), glioma (favourable) and lung cancer (unfavourable).
Urothelial cancer p<0.001 Glioma p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042867

GENE INFORMATION
Gene name	ADAMTS15
Synonyms
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 15 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.3
Chromosome location (bp)	130448974 - 130476641
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000166106 (version 83.38)
Entrez gene	170689
UniProt	Q8TE58 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TE58
Antibodypedia	ADAMTS15 antibodies

PROTEIN BROWSER

ADAMTS15-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS15-001 ENSP00000299164 ENST00000299164	Q8TE58 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 15 Show all	Enzymes Peptidases Metallopeptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	950 aa 103.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.