Expression of AMN in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AMN
Gene description	Amnion associated transmembrane protein
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, Hep G2, U-698)
HPA (normal tissue):	Group enriched (colon, duodenum, kidney, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in small intestines, kidney and colon.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA000817
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA000817

GENE INFORMATION
Gene name	AMN (HGNC Symbol)
Synonyms	amnionless
Description	Amnion associated transmembrane protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.32
Chromosome location (bp)	102922656 - 102933596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166126 (version 83.38)
Entrez gene	81693
UniProt	Q9BXJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXJ7
Antibodypedia	AMN antibodies

PROTEIN BROWSER

AMN-001	AMN-006	AMN-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMN-001 ENSP00000299155 ENST00000299155	Q9BXJ7 [Direct mapping] Protein amnionless Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0007588 [excretion] GO:0008104 [protein localization] GO:0009235 [cobalamin metabolic process] GO:0010008 [endosome membrane] GO:0015889 [cobalamin transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030139 [endocytic vesicle] GO:0042157 [lipoprotein metabolic process] GO:0043001 [Golgi to plasma membrane protein transport] GO:0044281 [small molecule metabolic process] GO:0045177 [apical part of cell] GO:0070062 [extracellular exosome] Show all	453 aa 47.8 kDa	Yes	1
AMN-006 ENSP00000453786 ENST00000559525	H0YMX8 [Direct mapping] Protein amnionless Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.2 kDa	No	0
AMN-007 ENSP00000452831 ENST00000559789	H0YKJ5 [Direct mapping] Protein amnionless Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	131 aa 13.7 kDa	No	1