Tissue expression of AMN - Summary - The Human Protein Atlas

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AMN

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	AMN
Gene description	Amnion associated transmembrane protein
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (colon, duodenum, kidney, small intestine)
GTEx:	Group enriched (colon, kidney, liver, small intestine)
FANTOM5:	Tissue enhanced (colon, small intestine)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several tissues, most abundant in small intestines, kidney and colon.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA000817
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

N/A

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

N/A

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, duodenum, kidney, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, kidney, liver, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, small intestine)

GENE INFORMATION
Gene name	AMN (HGNC Symbol)
Synonyms	amnionless
Description	Amnion associated transmembrane protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q32.32
Chromosome location (bp)	102922656 - 102933596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166126 (version 83.38)
Entrez gene	81693
UniProt	Q9BXJ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXJ7
Antibodypedia	AMN antibodies

PROTEIN BROWSER

AMN-001	AMN-006	AMN-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AMN-001 ENSP00000299155 ENST00000299155	Q9BXJ7 [Direct mapping] Protein amnionless Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006898 [receptor-mediated endocytosis] GO:0007275 [multicellular organismal development] GO:0007588 [excretion] GO:0008104 [protein localization] GO:0009235 [cobalamin metabolic process] GO:0010008 [endosome membrane] GO:0015889 [cobalamin transport] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030139 [endocytic vesicle] GO:0042157 [lipoprotein metabolic process] GO:0043001 [Golgi to plasma membrane protein transport] GO:0044281 [small molecule metabolic process] GO:0045177 [apical part of cell] GO:0070062 [extracellular exosome] Show all	453 aa 47.8 kDa	Yes	1
AMN-006 ENSP00000453786 ENST00000559525	H0YMX8 [Direct mapping] Protein amnionless Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 11.2 kDa	No	0
AMN-007 ENSP00000452831 ENST00000559789	H0YKJ5 [Direct mapping] Protein amnionless Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	131 aa 13.7 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.