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BRD7

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GENERAL INFORMATION

Gene name

 BRD7

Gene description

 Bromodomain containing 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA042389 , HPA060171
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & nucleoplasm.

Main location

 Nucleoplasm (supported), Cytosol (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042389 CACO-2 Nucleoplasm
Cytosol
HPA042389 Hep G2 Nucleoplasm
Cytosol
HPA042389 U-2 OS Nucleoplasm
Cytosol
HPA060171 HEK 293 Nucleus
Cytosol
HPA060171 Hep G2 Nucleus
Cytosol
HPA060171 U-2 OS Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 BRD7 (HGNC Symbol)

Synonyms

 BP75, CELTIX1

Description

 Bromodomain containing 7 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

Chromosome

 16

Cytoband

 q12.1

Chromosome location (bp)

 50313487 - 50368934

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166164 (version 83.38)

Entrez gene

 29117

UniProt

 Q9NPI1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NPI1

Antibodypedia

 BRD7 antibodies

PROTEIN BROWSER
BRD7-001
BRD7-002
BRD7-008
BRD7-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BRD7-001
ENSP00000378180
ENST00000394688
Q9NPI1 [Direct mapping]
Bromodomain-containing protein 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070577 [lysine-acetylated histone binding]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 651 aa
74.1 kDa 		No 0
BRD7-002
ENSP00000378181
ENST00000394689
Q9NPI1 [Direct mapping]
Bromodomain-containing protein 7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007049 [cell cycle]
GO:0008134 [transcription factor binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0016055 [Wnt signaling pathway]
GO:0035066 [positive regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0070577 [lysine-acetylated histone binding]
GO:0090544 [BAF-type complex]
GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle]
Show all
 652 aa
74.3 kDa 		No 0
BRD7-008
ENSP00000461556
ENST00000569774
I3L4V5 [Direct mapping]
Bromodomain-containing protein 7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 109 aa
12.1 kDa 		No 0
BRD7-009
ENSP00000458430
ENST00000562383
I3L0Y7 [Direct mapping]
Bromodomain-containing protein 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 32 aa
3.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.