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NOLC1

GENERAL INFORMATION

Gene name

 NOLC1

Gene description

 Nucleolar and coiled-body phosphoprotein 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Low nucleolar and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA037366 , HPA050388 , CAB032654
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA037366
HPA050388
CAB032654

GENE INFORMATION

Gene name

 NOLC1 (HGNC Symbol)

Synonyms

 KIAA0035, NOPP130, NOPP140, P130

Description

 Nucleolar and coiled-body phosphoprotein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 10

Cytoband

 q24.32

Chromosome location (bp)

 102152176 - 102163871

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166197 (version 83.38)

Entrez gene

 9221

UniProt

 Q14978 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14978

Antibodypedia

 NOLC1 antibodies

PROTEIN BROWSER
NOLC1-001
NOLC1-003
NOLC1-004
NOLC1-008
NOLC1-009
NOLC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOLC1-001
ENSP00000474710
ENST00000605788
Q14978 [Direct mapping]
Nucleolar and coiled-body phosphoprotein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0044822 [poly(A) RNA binding]
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 699 aa
73.6 kDa 		No 0
NOLC1-003
ENSP00000474140
ENST00000476468
S4R3C2 [Direct mapping]
Nucleolar and coiled-body phosphoprotein 1
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
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 281 aa
29.2 kDa 		No 0
NOLC1-004
ENSP00000473927
ENST00000461421
S4R349 [Direct mapping]
Nucleolar and coiled-body phosphoprotein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 258 aa
26.8 kDa 		No 0
NOLC1-008
ENSP00000359024
ENST00000370007
A0A0A0MRM9 [Direct mapping]
Nucleolar and coiled-body phosphoprotein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
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 708 aa
74.5 kDa 		No 0
NOLC1-009
ENSP00000475080
ENST00000488254
Q14978 [Direct mapping]
Nucleolar and coiled-body phosphoprotein 1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0044822 [poly(A) RNA binding]
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 700 aa
73.7 kDa 		No 0
NOLC1-201
ENSP00000385410
ENST00000405356
Q14978 [Direct mapping]
Nucleolar and coiled-body phosphoprotein 1
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005525 [GTP binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006364 [rRNA processing]
GO:0007000 [nucleolus organization]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
GO:0015030 [Cajal body]
GO:0044822 [poly(A) RNA binding]
Show all
 709 aa
74.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.