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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TPP1
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TPP1

Gene description

Tripeptidyl peptidase I

Protein class

Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous expression in lysosomes.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA037709 , HPA044868
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable), head and neck cancer (unfavourable) and stomach cancer (unfavourable).
Liver cancer p<0.001
Head and neck cancer p<0.001
Stomach cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA037709
HPA044868

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas and prostate cancers along with several cases of melanomas, gliomas and carcinoids as well as endometrial and renal cancers displayed moderate to strong granular cytoplasmic positivity. Remaining cancers were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases in most cancer tissues displayed moderate to strong granular cytoplasmic positivity. Rare cases of skin, urothelial and cervical cancers showed moderate cytoplasmic and nuclear positivity. Testicular and colorectal cancers were negative.

GENE INFORMATION

Gene name

TPP1 (HGNC Symbol)

Synonyms

CLN2, SCAR7

Description

Tripeptidyl peptidase I (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

6612763 - 6619461

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166340 (version 83.38)

Entrez gene

1200

UniProt

O14773 (UniProt - Evidence at protein level)

neXtProt

NX_O14773

Antibodypedia

TPP1 antibodies

PROTEIN BROWSER

TPP1-001
TPP1-003
TPP1-008
TPP1-019
TPP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPP1-001
ENSP00000299427
ENST00000299427
O14773 [Direct mapping]
Tripeptidyl-peptidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0007040 [lysosome organization]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0030163 [protein catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042277 [peptide binding]
GO:0042470 [melanosome]
GO:0043171 [peptide catabolic process]
GO:0043202 [lysosomal lumen]
GO:0044267 [cellular protein metabolic process]
GO:0045453 [bone resorption]
GO:0046872 [metal ion binding]
GO:0050885 [neuromuscular process controlling balance]
GO:0070062 [extracellular exosome]
Show all
563 aa
61.2 kDa
Yes 0
TPP1-003
ENSP00000437066
ENST00000533371
O14773 [Direct mapping]
Tripeptidyl-peptidase 1
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004175 [endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0007040 [lysosome organization]
GO:0007399 [nervous system development]
GO:0007417 [central nervous system development]
GO:0008233 [peptidase activity]
GO:0008236 [serine-type peptidase activity]
GO:0008240 [tripeptidyl-peptidase activity]
GO:0030163 [protein catabolic process]
GO:0030855 [epithelial cell differentiation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0042277 [peptide binding]
GO:0042470 [melanosome]
GO:0043171 [peptide catabolic process]
GO:0043202 [lysosomal lumen]
GO:0044267 [cellular protein metabolic process]
GO:0045453 [bone resorption]
GO:0046872 [metal ion binding]
GO:0050885 [neuromuscular process controlling balance]
GO:0070062 [extracellular exosome]
Show all
320 aa
34.5 kDa
No 0
TPP1-008
ENSP00000435001
ENST00000528657
E9PME9 [Direct mapping]
Tripeptidyl-peptidase 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007417 [central nervous system development]
Show all
30 aa
3.3 kDa
Yes 0
TPP1-019
ENSP00000398136
ENST00000436873
E7EV34 [Direct mapping]
Tripeptidyl-peptidase 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0007417 [central nervous system development]
GO:0008236 [serine-type peptidase activity]
Show all
177 aa
19.4 kDa
Yes 0
TPP1-201
ENSP00000484546
ENST00000611494
A0A0C4DGZ9 [Direct mapping]
Tripeptidyl-peptidase 1
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0007417 [central nervous system development]
GO:0008236 [serine-type peptidase activity]
Show all
556 aa
60.5 kDa
Yes 0

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