Tissue expression of TPP1 - Summary - The Human Protein Atlas

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TPP1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TPP1
Gene description	Tripeptidyl peptidase I
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous expression in lysosomes.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA037709 , HPA044868
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TPP1 (HGNC Symbol)
Synonyms	CLN2, SCAR7
Description	Tripeptidyl peptidase I (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	6612763 - 6619461
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166340 (version 83.38)
Entrez gene	1200
UniProt	O14773 (UniProt - Evidence at protein level)
neXtProt	NX_O14773
Antibodypedia	TPP1 antibodies

PROTEIN BROWSER

TPP1-001	TPP1-003	TPP1-008	TPP1-019	TPP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TPP1-001 ENSP00000299427 ENST00000299427	O14773 [Direct mapping] Tripeptidyl-peptidase 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0007040 [lysosome organization] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008240 [tripeptidyl-peptidase activity] GO:0030163 [protein catabolic process] GO:0030855 [epithelial cell differentiation] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042277 [peptide binding] GO:0042470 [melanosome] GO:0043171 [peptide catabolic process] GO:0043202 [lysosomal lumen] GO:0044267 [cellular protein metabolic process] GO:0045453 [bone resorption] GO:0046872 [metal ion binding] GO:0050885 [neuromuscular process controlling balance] GO:0070062 [extracellular exosome] Show all	563 aa 61.2 kDa	Yes	0
TPP1-003 ENSP00000437066 ENST00000533371	O14773 [Direct mapping] Tripeptidyl-peptidase 1 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004175 [endopeptidase activity] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005764 [lysosome] GO:0006508 [proteolysis] GO:0006629 [lipid metabolic process] GO:0007040 [lysosome organization] GO:0007399 [nervous system development] GO:0007417 [central nervous system development] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008240 [tripeptidyl-peptidase activity] GO:0030163 [protein catabolic process] GO:0030855 [epithelial cell differentiation] GO:0030968 [endoplasmic reticulum unfolded protein response] GO:0036498 [IRE1-mediated unfolded protein response] GO:0042277 [peptide binding] GO:0042470 [melanosome] GO:0043171 [peptide catabolic process] GO:0043202 [lysosomal lumen] GO:0044267 [cellular protein metabolic process] GO:0045453 [bone resorption] GO:0046872 [metal ion binding] GO:0050885 [neuromuscular process controlling balance] GO:0070062 [extracellular exosome] Show all	320 aa 34.5 kDa	No	0
TPP1-008 ENSP00000435001 ENST00000528657	E9PME9 [Direct mapping] Tripeptidyl-peptidase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007417 [central nervous system development] Show all	30 aa 3.3 kDa	Yes	0
TPP1-019 ENSP00000398136 ENST00000436873	E7EV34 [Direct mapping] Tripeptidyl-peptidase 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006508 [proteolysis] GO:0007417 [central nervous system development] GO:0008236 [serine-type peptidase activity] Show all	177 aa 19.4 kDa	Yes	0
TPP1-201 ENSP00000484546 ENST00000611494	A0A0C4DGZ9 [Direct mapping] Tripeptidyl-peptidase 1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] GO:0007417 [central nervous system development] GO:0008236 [serine-type peptidase activity] Show all	556 aa 60.5 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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