Fields »
ABOUT
HELP
BLOG
NETO1

GENERAL INFORMATION

Gene name

 NETO1

Gene description

 Neuropilin (NRP) and tolloid (TLL)-like 1

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (MOLT-4, REH, RPMI-8226, RT4, SCLC-21H)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 NETO1 (HGNC Symbol)

Synonyms

 BCTL1, BTCL1

Description

 Neuropilin (NRP) and tolloid (TLL)-like 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 18

Cytoband

 q22.3

Chromosome location (bp)

 72742314 - 72868146

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166342 (version 83.38)

Entrez gene

 81832

UniProt

 Q8TDF5 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q8TDF5

Antibodypedia

 NETO1 antibodies

PROTEIN BROWSER
NETO1-001
NETO1-002
NETO1-003
NETO1-006
NETO1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NETO1-001
ENSP00000313088
ENST00000327305
Q8TDF5 [Direct mapping]
Neuropilin and tolloid-like protein 1
A0A024R375 [Target identity:100%; Query identity:100%]
Neuropilin (NRP) and tolloid (TLL)-like 1, isoform CRA_a
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007613 [memory]
GO:0008542 [visual learning]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0035255 [ionotropic glutamate receptor binding]
GO:0045202 [synapse]
GO:0045211 [postsynaptic membrane]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0060076 [excitatory synapse]
GO:0097120 [receptor localization to synapse]
GO:2000463 [positive regulation of excitatory postsynaptic potential]
Show all
 533 aa
60.2 kDa 		Yes 1
NETO1-002
ENSP00000381024
ENST00000397929
Q8TDF5 [Direct mapping]
Neuropilin and tolloid-like protein 1
Show all
Transporters
   Accessory Factors Involved in Transport
   Phobius predicted secreted proteins
Predicted intracellular proteins
Show all
GO:0005576 [extracellular region]
GO:0007613 [memory]
GO:0008542 [visual learning]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0045211 [postsynaptic membrane]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0060076 [excitatory synapse]
Show all
 156 aa
17.7 kDa 		No 0
NETO1-003
ENSP00000464312
ENST00000583169
Q8TDF5 [Direct mapping]
Neuropilin and tolloid-like protein 1
A0A024R375 [Target identity:100%; Query identity:100%]
Neuropilin (NRP) and tolloid (TLL)-like 1, isoform CRA_a
Show all
Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007613 [memory]
GO:0008542 [visual learning]
GO:0014069 [postsynaptic density]
GO:0030054 [cell junction]
GO:0032983 [kainate selective glutamate receptor complex]
GO:0045211 [postsynaptic membrane]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0060076 [excitatory synapse]
Show all
 533 aa
60.2 kDa 		Yes 1
NETO1-006
ENSP00000464188
ENST00000579169
J3QRF5 [Direct mapping]
Neuropilin and tolloid-like protein 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0032983 [kainate selective glutamate receptor complex]
GO:0048168 [regulation of neuronal synaptic plasticity]
Show all
 101 aa
11.5 kDa 		Yes 0
NETO1-007
ENSP00000462993
ENST00000582281
Predicted intracellular proteins
Show all
 3 aa
0.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.