Tissue expression of NETO1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NETO1
Gene description	Neuropilin (NRP) and tolloid (TLL)-like 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (cerebral cortex)
GTEx:	Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, spleen)
FANTOM5:	Tissue enhanced (brain, caudate, hippocampus)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (caudate, cerebral cortex, hippocampus, hypothalamus, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (brain, caudate, hippocampus)

GENE INFORMATION
Gene name	NETO1 (HGNC Symbol)
Synonyms	BCTL1, BTCL1
Description	Neuropilin (NRP) and tolloid (TLL)-like 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a predicted transmembrane protein containing two extracellular CUB domains followed by a low-density lipoprotein class A (LDLa) domain. A similar gene in mice encodes a protein that plays a critical role in spatial learning and memory by regulating the function of synaptic N-methyl-D-aspartic acid receptor complexes in the hippocampus. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Chromosome	18
Cytoband	q22.3
Chromosome location (bp)	72742314 - 72868146
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166342 (version 83.38)
Entrez gene	81832
UniProt	Q8TDF5 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TDF5
Antibodypedia	NETO1 antibodies

PROTEIN BROWSER

NETO1-001	NETO1-002	NETO1-003	NETO1-006	NETO1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NETO1-001 ENSP00000313088 ENST00000327305	Q8TDF5 [Direct mapping] Neuropilin and tolloid-like protein 1 A0A024R375 [Target identity:100%; Query identity:100%] Neuropilin (NRP) and tolloid (TLL)-like 1, isoform CRA_a Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007613 [memory] GO:0008542 [visual learning] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0032983 [kainate selective glutamate receptor complex] GO:0035255 [ionotropic glutamate receptor binding] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0060076 [excitatory synapse] GO:0097120 [receptor localization to synapse] GO:2000463 [positive regulation of excitatory postsynaptic potential] Show all	533 aa 60.2 kDa	Yes	1
NETO1-002 ENSP00000381024 ENST00000397929	Q8TDF5 [Direct mapping] Neuropilin and tolloid-like protein 1 Show all	Transporters Accessory Factors Involved in Transport Phobius predicted secreted proteins Predicted intracellular proteins Show all	GO:0005576 [extracellular region] GO:0007613 [memory] GO:0008542 [visual learning] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0032983 [kainate selective glutamate receptor complex] GO:0045211 [postsynaptic membrane] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0060076 [excitatory synapse] Show all	156 aa 17.7 kDa	No	0
NETO1-003 ENSP00000464312 ENST00000583169	Q8TDF5 [Direct mapping] Neuropilin and tolloid-like protein 1 A0A024R375 [Target identity:100%; Query identity:100%] Neuropilin (NRP) and tolloid (TLL)-like 1, isoform CRA_a Show all	Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007613 [memory] GO:0008542 [visual learning] GO:0014069 [postsynaptic density] GO:0030054 [cell junction] GO:0032983 [kainate selective glutamate receptor complex] GO:0045211 [postsynaptic membrane] GO:0048169 [regulation of long-term neuronal synaptic plasticity] GO:0060076 [excitatory synapse] Show all	533 aa 60.2 kDa	Yes	1
NETO1-006 ENSP00000464188 ENST00000579169	J3QRF5 [Direct mapping] Neuropilin and tolloid-like protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0032983 [kainate selective glutamate receptor complex] GO:0048168 [regulation of neuronal synaptic plasticity] Show all	101 aa 11.5 kDa	Yes	0
NETO1-007 ENSP00000462993 ENST00000582281		Predicted intracellular proteins Show all		3 aa 0.3 kDa	No	0