Cell atlas - PPFIBP2 - The Human Protein Atlas

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PPFIBP2

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	PPFIBP2
Gene description	PTPRF interacting protein, binding protein 2 (liprin beta 2)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Cell line enhanced (RT4, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001935
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RT4, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001935	A-431	Mitochondria
	HPA001935	U-2 OS	Mitochondria
	HPA001935	U-251 MG	Mitochondria

GENE INFORMATION
Gene name	PPFIBP2 (HGNC Symbol)
Synonyms	Cclp1
Description	PTPRF interacting protein, binding protein 2 (liprin beta 2) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. The encoded protein is a beta liprin and plays a role in axon guidance and neuronal synapse development by recruiting LAR protein-tyrosine phosphatases to the plasma membrane. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	7513298 - 7657127
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166387 (version 83.38)
Entrez gene	8495
UniProt	Q8ND30 (UniProt - Evidence at protein level)
neXtProt	NX_Q8ND30
Antibodypedia	PPFIBP2 antibodies

PROTEIN BROWSER

PPFIBP2-001	PPFIBP2-003	PPFIBP2-007	PPFIBP2-008	PPFIBP2-011	PPFIBP2-012	PPFIBP2-013	PPFIBP2-014	PPFIBP2-015	PPFIBP2-017	PPFIBP2-022	PPFIBP2-023	PPFIBP2-028	PPFIBP2-029

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPFIBP2-001 ENSP00000299492 ENST00000299492	Q8ND30 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] Show all	876 aa 98.5 kDa	No	0
PPFIBP2-003 ENSP00000436498 ENST00000533792	E9PP16 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	718 aa 81.4 kDa	No	0
PPFIBP2-007 ENSP00000435469 ENST00000528883	Q8ND30 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] Show all	764 aa 86.5 kDa	No	0
PPFIBP2-008 ENSP00000437321 ENST00000530181	Q8ND30 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005622 [intracellular] Show all	733 aa 83.2 kDa	No	0
PPFIBP2-011 ENSP00000434641 ENST00000526873	E9PK17 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.5 kDa	No	0
PPFIBP2-012 ENSP00000431724 ENST00000528947	E9PK17 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		89 aa 9.5 kDa	No	0
PPFIBP2-013 ENSP00000434981 ENST00000527790	E9PMH3 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.6 kDa	No	0
PPFIBP2-014 ENSP00000433026 ENST00000526046	E9PMN3 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		70 aa 7.4 kDa	No	0
PPFIBP2-015 ENSP00000435794 ENST00000529575	E9PIK8 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		155 aa 18.4 kDa	No	0
PPFIBP2-017 ENSP00000433839 ENST00000525597	E9PJA0 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 10.4 kDa	No	0
PPFIBP2-022 ENSP00000433713 ENST00000534409	H0YDJ2 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		225 aa 24.1 kDa	No	0
PPFIBP2-023 ENSP00000436739 ENST00000530081	E9PI79 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		182 aa 19.3 kDa	No	0
PPFIBP2-028 ENSP00000436489 ENST00000534552	H0YET1 [Direct mapping] Liprin-beta-2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		149 aa 16.8 kDa	No	0
PPFIBP2-029 ENSP00000433917 ENST00000524548	H0YDM0 [Direct mapping] Liprin-beta-2 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.