Expression of IDH3A in cancer - Summary - The Human Protein Atlas

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IDH3A

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IDH3A
Gene description	Isocitrate dehydrogenase 3 (NAD+) alpha
Protein class	Citric acid cycle related proteins Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 1 antibody. HPA041465
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041465

GENE INFORMATION
Gene name	IDH3A
Synonyms
Description	Isocitrate dehydrogenase 3 (NAD+) alpha (HGNC Symbol)
Entrez gene summary	Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q25.1
Chromosome location (bp)	78131498 - 78171949
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166411 (version 83.38)
Entrez gene	3419
UniProt	P50213 (UniProt - Evidence at protein level)
neXtProt	NX_P50213
Antibodypedia	IDH3A antibodies

PROTEIN BROWSER

IDH3A-001	IDH3A-006	IDH3A-012	IDH3A-014	IDH3A-015	IDH3A-016	IDH3A-017	IDH3A-018	IDH3A-022	IDH3A-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IDH3A-001 ENSP00000299518 ENST00000299518	P50213 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0043209 [myelin sheath] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	366 aa 39.6 kDa	No	0
IDH3A-006 ENSP00000453084 ENST00000558554	H0YL72 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	331 aa 35.8 kDa	No	0
IDH3A-012 ENSP00000452754 ENST00000559186	H0YKD0 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	109 aa 12.1 kDa	No	0
IDH3A-014 ENSP00000453222 ENST00000559881	H0YLI6 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	134 aa 14.8 kDa	No	0
IDH3A-015 ENSP00000453903 ENST00000560770	A0A0G2JL95 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all		8 aa 0.9 kDa	No	0
IDH3A-016 ENSP00000453480 ENST00000557826	H0YM64 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	46 aa 5.2 kDa	No	0
IDH3A-017 ENSP00000453989 ENST00000559205	H0YNF5 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	87 aa 9.3 kDa	No	0
IDH3A-018 ENSP00000453795 ENST00000561366	H0YMY5 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0055114 [oxidation-reduction process] Show all	45 aa 5.2 kDa	No	0
IDH3A-022 ENSP00000453747 ENST00000561279	H0YMU3 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	175 aa 19.2 kDa	No	0
IDH3A-201 ENSP00000485769 ENST00000629769	Q68D72 [Direct mapping] Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Putative uncharacterized protein DKFZp686A08194 Show all	Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4 kDa	No	0

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