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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Citric acid cycle related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0004449 [isocitrate dehydrogenase (NAD+) activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0005975 [carbohydrate metabolic process] GO:0006099 [tricarboxylic acid cycle] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0043209 [myelin sheath] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
Predicted intracellular proteins Citric acid cycle related proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding] GO:0005739 [mitochondrion] GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process]
