Expression of WDR72 in cancer - Summary

GENERAL INFORMATION
Gene name	WDR72
Gene description	WD repeat domain 72
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, EFO-21, NTERA-2, RPMI-8226, RPTEC TERT1)
HPA (normal tissue):	Group enriched (kidney, thyroid gland)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues, including kidney and thyroid gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA057410 , HPA059819
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057410	HPA059819

GENE INFORMATION
Gene name	WDR72 (HGNC Symbol)
Synonyms	FLJ38736
Description	WD repeat domain 72 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with eight WD-40 repeats. Mutations in this gene have been associated with amelogenesis imperfecta hypomaturation type 2A3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Chromosome	15
Cytoband	q21.3
Chromosome location (bp)	53513741 - 53762878
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000166415 (version 83.38)
Entrez gene	256764
UniProt	Q3MJ13 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3MJ13
Antibodypedia	WDR72 antibodies

PROTEIN BROWSER

WDR72-001	WDR72-002	WDR72-003	WDR72-004	WDR72-005	WDR72-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
WDR72-001 ENSP00000379619 ENST00000396328	Q3MJ13 [Direct mapping] WD repeat-containing protein 72 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0070166 [enamel mineralization] Show all	1102 aa 123.4 kDa	No	0
WDR72-002 ENSP00000353699 ENST00000360509	Q3MJ13 [Direct mapping] WD repeat-containing protein 72 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Disease related genes Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	1102 aa 123.4 kDa	No	0
WDR72-003 ENSP00000453378 ENST00000557913	H0YLX4 [Direct mapping] WD repeat-containing protein 72 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	1099 aa 123 kDa	No	0
WDR72-004 ENSP00000453813 ENST00000560036	H0YN02 [Direct mapping] WD repeat-containing protein 72 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	775 aa 86.8 kDa	No	0
WDR72-005 ENSP00000452765 ENST00000559418	H0YKE0 [Direct mapping] WD repeat-containing protein 72 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	1112 aa 124.6 kDa	No	0
WDR72-201 ENSP00000477754 ENST00000614174	A0A087WTC3 [Direct mapping] WD repeat-containing protein 72 Show all	Predicted intracellular proteins Show all		88 aa 9.3 kDa	No	0