Cell atlas - LEO1 - The Human Protein Atlas

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LEO1

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS GFP

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli fibrillar center
	Nucleoplasm

Human cell
	Nucleoli
	Nucleoplasm

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GENERAL INFORMATION
Gene name	LEO1
Gene description	LEO1 homolog, Paf1/RNA polymerase II complex component
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the nucleoli (fibrillar center).
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Nucleoli fibrillar center (validated)
Single-cell variation	Single-cell variation in protein expression observed.
GFP	The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY
Reliability score	Validated based on 1 antibody. HPA040741
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the nucleoli (fibrillar center).

Main location

Nucleoplasm (validated)

Additional location

Nucleoli fibrillar center (validated)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040741	A-431	Nucleoplasm
	HPA040741	U-2 OS	Nucleoplasm
			Nucleoli fibrillar center
			Centrosome	Intensity
	HPA040741	U-251 MG	Nucleoplasm
			Nucleoli fibrillar center
			Centrosome

GFP

Antibody	HPA040741
Validation	C-terminal tag BAC cell line: 2493 Validated: Antibody staining overlaps with GFP tagged protein


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	BAC id	Tag	Location antibody staining	Location tagged protein
	HPA040741	HeLa	2493	C-terminal	Nucleoplasm, Nucleoli fibrillar center	Nucleoplasm, Nucleoli fibrillar center
	HPA040741	HeLa	Normal	-	Nucleoplasm, Nucleoli fibrillar center	-

GENE INFORMATION
Gene name	LEO1
Synonyms
Description	LEO1 homolog, Paf1/RNA polymerase II complex component (HGNC Symbol)
Entrez gene summary	LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Chromosome	15
Cytoband	q21.2
Chromosome location (bp)	51938025 - 51971806
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166477 (version 83.38)
Entrez gene	123169
UniProt	Q8WVC0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVC0
Antibodypedia	LEO1 antibodies

PROTEIN BROWSER

LEO1-001	LEO1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LEO1-001 ENSP00000299601 ENST00000299601	Q8WVC0 [Direct mapping] RNA polymerase-associated protein LEO1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001711 [endodermal cell fate commitment] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006378 [mRNA polyadenylation] GO:0010390 [histone monoubiquitination] GO:0016055 [Wnt signaling pathway] GO:0016570 [histone modification] GO:0016593 [Cdc73/Paf1 complex] GO:0019827 [stem cell population maintenance] GO:0031442 [positive regulation of mRNA 3'-end processing] GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter] GO:0033523 [histone H2B ubiquitination] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1990269 [RNA polymerase II C-terminal domain phosphoserine binding] Show all	666 aa 75.4 kDa	No	0
LEO1-002 ENSP00000314610 ENST00000315141	Q8WVC0 [Direct mapping] RNA polymerase-associated protein LEO1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001711 [endodermal cell fate commitment] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0006378 [mRNA polyadenylation] GO:0010390 [histone monoubiquitination] GO:0016055 [Wnt signaling pathway] GO:0016570 [histone modification] GO:0016593 [Cdc73/Paf1 complex] GO:0019827 [stem cell population maintenance] GO:0031442 [positive regulation of mRNA 3'-end processing] GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter] GO:0033523 [histone H2B ubiquitination] GO:0045638 [negative regulation of myeloid cell differentiation] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:1990269 [RNA polymerase II C-terminal domain phosphoserine binding] Show all	606 aa 68 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.