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LEO1

GENERAL INFORMATION

Gene name

 LEO1

Gene description

 LEO1 homolog, Paf1/RNA polymerase II complex component

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA040741 , HPA040941
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA040741
HPA040941

GENE INFORMATION

Gene name

 LEO1

Synonyms

Description

 LEO1 homolog, Paf1/RNA polymerase II complex component (HGNC Symbol)

Entrez gene summary

 LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

Chromosome

 15

Cytoband

 q21.2

Chromosome location (bp)

 51938025 - 51971806

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166477 (version 83.38)

Entrez gene

 123169

UniProt

 Q8WVC0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WVC0

Antibodypedia

 LEO1 antibodies

PROTEIN BROWSER
LEO1-001
LEO1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LEO1-001
ENSP00000299601
ENST00000299601
Q8WVC0 [Direct mapping]
RNA polymerase-associated protein LEO1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001711 [endodermal cell fate commitment]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006378 [mRNA polyadenylation]
GO:0010390 [histone monoubiquitination]
GO:0016055 [Wnt signaling pathway]
GO:0016570 [histone modification]
GO:0016593 [Cdc73/Paf1 complex]
GO:0019827 [stem cell population maintenance]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0033523 [histone H2B ubiquitination]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1990269 [RNA polymerase II C-terminal domain phosphoserine binding]
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 666 aa
75.4 kDa 		No 0
LEO1-002
ENSP00000314610
ENST00000315141
Q8WVC0 [Direct mapping]
RNA polymerase-associated protein LEO1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001711 [endodermal cell fate commitment]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006378 [mRNA polyadenylation]
GO:0010390 [histone monoubiquitination]
GO:0016055 [Wnt signaling pathway]
GO:0016570 [histone modification]
GO:0016593 [Cdc73/Paf1 complex]
GO:0019827 [stem cell population maintenance]
GO:0031442 [positive regulation of mRNA 3'-end processing]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0033523 [histone H2B ubiquitination]
GO:0045638 [negative regulation of myeloid cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:1990269 [RNA polymerase II C-terminal domain phosphoserine binding]
Show all
 606 aa
68 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.