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MAPK7

GENERAL INFORMATION

Gene name

 MAPK7

Gene description

 Mitogen-activated protein kinase 7

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Antibody staining mainly consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
CAB018561
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB018561

GENE INFORMATION

Gene name

 MAPK7 (HGNC Symbol)

Synonyms

 BMK1, ERK5, PRKM7

Description

 Mitogen-activated protein kinase 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p11.2

Chromosome location (bp)

 19377721 - 19383544

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000166484 (version 83.38)

Entrez gene

 5598

UniProt

 Q13164 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13164

Antibodypedia

 MAPK7 antibodies

PROTEIN BROWSER
MAPK7-001
MAPK7-002
MAPK7-003
MAPK7-004
MAPK7-005
MAPK7-015
MAPK7-018
MAPK7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK7-001
ENSP00000378966
ENST00000395602
Q13164 [Direct mapping]
Mitogen-activated protein kinase 7
A0A024QZ20 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016605 [PML body]
GO:0019933 [cAMP-mediated signaling]
GO:0030154 [cell differentiation]
GO:0030821 [negative regulation of cAMP catabolic process]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 816 aa
88.4 kDa 		No 0
MAPK7-002
ENSP00000378968
ENST00000395604
Q13164 [Direct mapping]
Mitogen-activated protein kinase 7
A0A024QZ20 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016605 [PML body]
GO:0019933 [cAMP-mediated signaling]
GO:0030154 [cell differentiation]
GO:0030821 [negative regulation of cAMP catabolic process]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 816 aa
88.4 kDa 		No 0
MAPK7-003
ENSP00000299612
ENST00000299612
Q13164 [Direct mapping]
Mitogen-activated protein kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016605 [PML body]
GO:0019933 [cAMP-mediated signaling]
GO:0030154 [cell differentiation]
GO:0030821 [negative regulation of cAMP catabolic process]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 677 aa
73.2 kDa 		No 0
MAPK7-004
ENSP00000458146
ENST00000482850
I3L0J8 [Direct mapping]
Mitogen-activated protein kinase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 196 aa
22.6 kDa 		No 0
MAPK7-005
ENSP00000412902
ENST00000443215
C9JUK9 [Direct mapping]
Mitogen-activated protein kinase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 241 aa
27.2 kDa 		No 0
MAPK7-015
ENSP00000462819
ENST00000579284
J3KT61 [Direct mapping]
Mitogen-activated protein kinase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 157 aa
17.2 kDa 		No 0
MAPK7-018
ENSP00000474397
ENST00000603493
S4R3I1 [Direct mapping]
Mitogen-activated protein kinase 7
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 144 aa
15.6 kDa 		No 0
MAPK7-201
ENSP00000311005
ENST00000308406
Q13164 [Direct mapping]
Mitogen-activated protein kinase 7
A0A024QZ20 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0016605 [PML body]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0019933 [cAMP-mediated signaling]
GO:0030154 [cell differentiation]
GO:0030821 [negative regulation of cAMP catabolic process]
GO:0034115 [negative regulation of heterotypic cell-cell adhesion]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043066 [negative regulation of apoptotic process]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045765 [regulation of angiogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050728 [negative regulation of inflammatory response]
GO:0051019 [mitogen-activated protein kinase binding]
GO:0051247 [positive regulation of protein metabolic process]
GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0051534 [negative regulation of NFAT protein import into nucleus]
GO:0060761 [negative regulation of response to cytokine stimulus]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070377 [negative regulation of ERK5 cascade]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071499 [cellular response to laminar fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Show all
 816 aa
88.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.