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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.
RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GENE INFORMATION
Gene name
MAPK7 (HGNC Symbol)
Synonyms
BMK1, ERK5, PRKM7
Description
Mitogen-activated protein kinase 7 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7 A0A024QZ20 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
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Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0016605 [PML body] GO:0019933 [cAMP-mediated signaling] GO:0030154 [cell differentiation] GO:0030821 [negative regulation of cAMP catabolic process] GO:0034115 [negative regulation of heterotypic cell-cell adhesion] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050728 [negative regulation of inflammatory response] GO:0051019 [mitogen-activated protein kinase binding] GO:0051247 [positive regulation of protein metabolic process] GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0051403 [stress-activated MAPK cascade] GO:0060761 [negative regulation of response to cytokine stimulus] GO:0070301 [cellular response to hydrogen peroxide] GO:0071363 [cellular response to growth factor stimulus] GO:0071499 [cellular response to laminar fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7 A0A024QZ20 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0016605 [PML body] GO:0019933 [cAMP-mediated signaling] GO:0030154 [cell differentiation] GO:0030821 [negative regulation of cAMP catabolic process] GO:0034115 [negative regulation of heterotypic cell-cell adhesion] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050728 [negative regulation of inflammatory response] GO:0051019 [mitogen-activated protein kinase binding] GO:0051247 [positive regulation of protein metabolic process] GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0051403 [stress-activated MAPK cascade] GO:0060761 [negative regulation of response to cytokine stimulus] GO:0070301 [cellular response to hydrogen peroxide] GO:0071363 [cellular response to growth factor stimulus] GO:0071499 [cellular response to laminar fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0016605 [PML body] GO:0019933 [cAMP-mediated signaling] GO:0030154 [cell differentiation] GO:0030821 [negative regulation of cAMP catabolic process] GO:0034115 [negative regulation of heterotypic cell-cell adhesion] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050728 [negative regulation of inflammatory response] GO:0051019 [mitogen-activated protein kinase binding] GO:0051247 [positive regulation of protein metabolic process] GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0051403 [stress-activated MAPK cascade] GO:0060761 [negative regulation of response to cytokine stimulus] GO:0070301 [cellular response to hydrogen peroxide] GO:0071363 [cellular response to growth factor stimulus] GO:0071499 [cellular response to laminar fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]
Q13164 [Direct mapping] Mitogen-activated protein kinase 7 A0A024QZ20 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase
Show all
Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004707 [MAP kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0007049 [cell cycle] GO:0007165 [signal transduction] GO:0016605 [PML body] GO:0018105 [peptidyl-serine phosphorylation] GO:0019933 [cAMP-mediated signaling] GO:0030154 [cell differentiation] GO:0030821 [negative regulation of cAMP catabolic process] GO:0034115 [negative regulation of heterotypic cell-cell adhesion] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043066 [negative regulation of apoptotic process] GO:0043407 [negative regulation of MAP kinase activity] GO:0045087 [innate immune response] GO:0045765 [regulation of angiogenesis] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050728 [negative regulation of inflammatory response] GO:0051019 [mitogen-activated protein kinase binding] GO:0051247 [positive regulation of protein metabolic process] GO:0051344 [negative regulation of cyclic-nucleotide phosphodiesterase activity] GO:0051403 [stress-activated MAPK cascade] GO:0051534 [negative regulation of NFAT protein import into nucleus] GO:0060761 [negative regulation of response to cytokine stimulus] GO:0070301 [cellular response to hydrogen peroxide] GO:0070377 [negative regulation of ERK5 cascade] GO:0071363 [cellular response to growth factor stimulus] GO:0071499 [cellular response to laminar fluid shear stress] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1902176 [negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:2000352 [negative regulation of endothelial cell apoptotic process] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand]