Expression of CLEC4D in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CLEC4D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLEC4D
Gene description	C-type lectin domain family 4, member D
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (testis cancer)
HPA (cell line):	Cell line enhanced (NTERA-2, U-937)
HPA (normal tissue):	Group enriched (appendix, bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA004906
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004906

GENE INFORMATION
Gene name	CLEC4D (HGNC Symbol)
Synonyms	CD368, CLECSF8, Mpcl
Description	C-type lectin domain family 4, member D (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8509475 - 8522366
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000166527 (version 83.38)
Entrez gene	338339
UniProt	Q8WXI8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WXI8
Antibodypedia	CLEC4D antibodies

PROTEIN BROWSER

CLEC4D-001	CLEC4D-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC4D-001 ENSP00000299665 ENST00000299665	Q8WXI8 [Direct mapping] C-type lectin domain family 4 member D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002292 [T cell differentiation involved in immune response] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0030246 [carbohydrate binding] GO:0034987 [immunoglobulin receptor binding] GO:0038094 [Fc-gamma receptor signaling pathway] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	215 aa 24.7 kDa	No	1
CLEC4D-002 ENSP00000371496 ENST00000382064	A6NHA5 [Direct mapping] C-type lectin domain family 4 member D Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0016021 [integral component of membrane] Show all	144 aa 16.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.